[en] Belgian Blue cattle are known for their high degree of muscling and good carcass qualities. This high degree of muscling is mainly caused by a mutation in the myostatin gene (MSTN). Although the MSTN mutation is considered as fixed in the Belgian Blue breed, segregation is occurring in a sub-population bred for dual purpose. In the latter population, we observed an association between the mutation in MSTN and susceptibility to psoroptic mange, a skin disease caused by Psoroptes ovis mites that heavily plagues Belgian Blue cattle. In total, 291 animals were sampled and screened for their susceptibility for mange lesions and their MSTN genotype. Via linear mixed modelling, we observed that homozygous mutant animals had a significant increase in the size of mange lesions (+2.51% lesion extent) compared to homozygous wild type. These findings were confirmed with zero-inflated modelling, an animal model and odds analysis. Risk ratios for developing severe mange lesions were 5.9 times as high for homozygous mutant animals. All analyses confirmed an association between the MSTN genotype and psoroptic mange lesion size.
Disciplines :
Animal production & animal husbandry Genetics & genetic processes
Author, co-author :
Meyermans, R; Center for Animal Breeding and Genetics, Department of Biosystems, KU Leuven, 3001 Leuven, Belgium
Janssens, S; Center for Animal Breeding and Genetics, Department of Biosystems, KU Leuven, 3001 Leuven, Belgium
Coussé, A; Center for Animal Breeding and Genetics, Department of Biosystems, KU Leuven, 3001 Leuven, Belgium
Gorssen, W; Center for Animal Breeding and Genetics, Department of Biosystems, KU Leuven, 3001 Leuven, Belgium
Hubin, X; Elevéo asbl, 5590 Ciney, Belgium
Mayeres, P; Elevéo asbl, 5590 Ciney, Belgium
Veulemans, W; CRV, 6843 NW Arnhem, the Netherlands
Claerebout, E; Laboratory of Parasitology, Department Virology, Parasitology and Immunology, UGent, 9820 Merelbeke, Belgium
Charlier, Carole ; Université de Liège - ULiège > GIGA > GIGA Medical Genomics - Unit of Animal Genomics
Buys, N; Center for Animal Breeding and Genetics, Department of Biosystems, KU Leuven, 3001 Leuven, Belgium. Electronic address: nadine.buys@kuleuven.be
Language :
English
Title :
Myostatin mutation causing double muscling could affect increased psoroptic mange sensitivity in dual purpose Belgian Blue cattle.
This study was funded by the Federal Public Service of Health, Food Chain Safety and Environment (contract RT 11/5 PSOROVIS and RT 17/1 BOMANGE). This research is also funded by a SB PhD fellowship (1S37119N) [RM] and an FR PhD fellowship (1104320N) [WG] of the Research Foundation Flanders (FWO).The authors would like to thank all farmers for their cooperation and the Genomics core facility of GIGA for their excellent genotyping and support. The authors would like to thank Michel Georges for his input in the design and analysis of the study. Also, thanks to Susanne Tinel (KU Leuven), Nathalie De Wilde (UGent) and Fabrice Lepot (Elev?o asbl) for their excellent technical support. This study was funded by the Federal Public Service of Health, Food Chain Safety and Environment (contract RT 11/5 PSOROVIS and RT 17/1 BOMANGE). This research is also funded by a SB PhD fellowship (1S37119N) [RM] and an FR PhD fellowship (1104320N) [WG] of the Research Foundation Flanders (FWO).
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