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Lamellar Neutrophil Myeloperoxydase Infiltration in Hyperinsulinemic-Induced Laminitis
Storms, Nazaré; Medina Torres, Carlos; Franck, Thierry et al.
2021In Veterinary Surgery
Peer reviewed
 

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ECVS 2021-Presence of neutrophil myeloperoxidase in lamellar tissue of horses with laminitis induced using a hyperinsulinemic model.pdf
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Abstract :
[en] Introduction - Laminitis is a pathology of the equine digit resulting in failure of the dermo-epidermal interface. Inflammation is a central player in its pathophysiology. Neutrophil activation and the presence of myeloperoxidase have been observed in the black walnut heartwood extract model. However less is known about their role in the hyperinsulinemia model. Materials and methods - Five horses were included in the study and randomly assigned to a control group (n = 2) and a prolonged euglycemic hyperinsulinemic clamp (pEHC) group (n = 3). Histological sections of lamellar tissue from all horses were immunohistochemically stained for myeloperoxidase as well as counterstained with hematoxylin-eosin. The sections were examined for histopathological evidence of laminitis and myeloperoxidase. Results – Histopathological changes that characterize insulin-induced laminitis and increased presence of myeloperoxidase, especially in the dermal lamellae, were observed in histologic sections of pEHC-treated horses compared to control horses. Conclusion - Neutrophil activation with myeloperoxidase release may play a role in the pathophysiology of endocrinopathic laminitis. Their exact implications warrant further investigation.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Storms, Nazaré  ;  Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH)
Medina Torres, Carlos
Franck, Thierry  ;  Université de Liège - ULiège > Centres généraux > Centre de l'oxygène : Recherche et développement (C.O.R.D.)
Guitart, Albert
de la Rebière de Pouyade, Geoffroy  ;  Université de Liège - ULiège > Département d'Enseignement et de Clinique des Equidés (DCE) > Chirurgie des équidés
Serteyn, Didier  ;  Université de Liège - ULiège > Département d'Enseignement et de Clinique des Equidés (DCE) > Chirurgie des équidés
Language :
English
Title :
Lamellar Neutrophil Myeloperoxydase Infiltration in Hyperinsulinemic-Induced Laminitis
Publication date :
08 July 2021
Event name :
Annual scientific meeting European College of Veterinary Surgeons
Event organizer :
European College of Veterinary Surgeons
Event date :
8-10/07/2021
Audience :
International
Main work title :
Veterinary Surgery
Publisher :
Veterinary Surgery
Peer reviewed :
Peer reviewed
Available on ORBi :
since 11 March 2022

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