Article (Scientific journals)
Effects of supercritical carbon dioxide under conditions potentially conducive to sterilization on physicochemical characteristics of a liposome formulation containing apigenin
Delma, Kouka Luc; Penoy, Noémie; Grignard, Bruno et al.
2022In Journal of Supercritical Fluids, 179, p. 105418
Peer Reviewed verified by ORBi
 

Files


Full Text
DELMA KL - 2022 - J Supercrit CO2 - 179 - 105418.pdf
Publisher postprint (1.63 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Supercritical carbon dioxide; Apigenin; liposome
Abstract :
[en] In this work, the effects of four supercritical carbon dioxide (ScCO2) conditions potentially conductive to sterilization, on physicochemical characteristics of a liposome formulation containing apigenin (AG) were investigated. These conditions were: C1 (ScCO2/70 °C/150 bar/240 min), C2 (ScCO2/0.25% water/ 0.15% H2O2)/ 0.5% acetic anhydride/38 °C/85 bar/45 min), C3 (ScCO2/0.08% peracetic acid/35 °C/104 bar/180 min) and C4 (ScCO2/ 200 ppm H2O2/40 °C/270 bar/90 min). The results showed changes in color and a decrease in pH value of liposomes suspension after treatment with all tested conditions. Moreover, a decrease in liposome size with C1, C2 and C3 and an increase in the PDI with C1 and C3 were observed. For zeta potential, a decrease with C1, and an increase with C2 and C3 were found. Concerning the encapsulated AG, a moderate decrease, a strong decrease and a total disappearance were noted with conditions C1, C2 and C3 respectively.
Research Center/Unit :
CESAM - Complex and Entangled Systems from Atoms to Materials - ULiège
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège
CERM - Center for Education and Research on Macromolecules - ULiège
Disciplines :
Materials science & engineering
Chemistry
Pharmacy, pharmacology & toxicology
Author, co-author :
Delma, Kouka Luc ;  University Joseph KI-ZERBO, Laboratory of Drug Development, Burkina Faso > University of Liège (ULiège), Laboratory of Pharmaceutical Technology and Biopharmacy, Center for Interdisciplinary Research on Medicines (CIRM), Belgium
Penoy, Noémie  ;  University of Liège (ULiège), Laboratory of Pharmaceutical Technology and Biopharmacy, Center for Interdisciplinary Research on Medicines (CIRM), Belgium
Grignard, Bruno ;  University of Liège (ULiège), Complex and Entangled Systems from Atoms to Materials (CESAM) Research Unit, Center for Education and Research on Macromolecules (CERM), Belgium
Semdé, Rasmané;  Laboratory of Drug Development, Doctoral School of Sciences and Health, University Joseph KI-ZERBO, Burkina Faso
Evrard, Brigitte  ;  University of Liège (ULiège), Laboratory of Pharmaceutical Technology and Biopharmacy, Center for Interdisciplinary Research on Medicines (CIRM), Belgium
Piel, Géraldine  ;  University of Liège (ULiège), Laboratory of Pharmaceutical Technology and Biopharmacy, Center for Interdisciplinary Research on Medicines (CIRM), Belgium
Language :
English
Title :
Effects of supercritical carbon dioxide under conditions potentially conducive to sterilization on physicochemical characteristics of a liposome formulation containing apigenin
Publication date :
January 2022
Journal title :
Journal of Supercritical Fluids
ISSN :
0896-8446
Publisher :
Elsevier B.V.
Volume :
179
Pages :
105418
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
ARES CCD - Académie de Recherche et d'Enseignement Supérieur. Coopération au Développement
Funding text :
Authors would like to acknowledge the Academy for research and Higher Education-Development Cooperation Committee (ARES-CCD) for the financial support.
Available on ORBi :
since 10 March 2022

Statistics


Number of views
89 (17 by ULiège)
Number of downloads
11 (5 by ULiège)

Scopus citations®
 
5
Scopus citations®
without self-citations
2
OpenCitations
 
0
OpenAlex citations
 
5

Bibliography


Similar publications



Contact ORBi