Effects of supercritical carbon dioxide under conditions potentially conducive to sterilization on physicochemical characteristics of a liposome formulation containing apigenin

Delma, Kouka Luc; Penoy, Noémie; Grignard, Bruno; Semdé, Rasmané; Evrard, Brigitte; Piel, Géraldine

doi:10.1016/j.supflu.2021.105418

Article (Scientific journals)

Effects of supercritical carbon dioxide under conditions potentially conducive to sterilization on physicochemical characteristics of a liposome formulation containing apigenin

Delma, Kouka Luc; Penoy, Noémie; Grignard, Bruno et al.

2022 • In Journal of Supercritical Fluids, 179, p. 105418

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/288757

DOI
10.1016/j.supflu.2021.105418

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Keywords :

Supercritical carbon dioxide; Apigenin; liposome

Abstract :

[en] In this work, the effects of four supercritical carbon dioxide (ScCO2) conditions potentially conductive to sterilization, on physicochemical characteristics of a liposome formulation containing apigenin (AG) were investigated. These conditions were: C1 (ScCO2/70 °C/150 bar/240 min), C2 (ScCO2/0.25% water/ 0.15% H2O2)/ 0.5% acetic anhydride/38 °C/85 bar/45 min), C3 (ScCO2/0.08% peracetic acid/35 °C/104 bar/180 min) and C4 (ScCO2/ 200 ppm H2O2/40 °C/270 bar/90 min). The results showed changes in color and a decrease in pH value of liposomes suspension after treatment with all tested conditions. Moreover, a decrease in liposome size with C1, C2 and C3 and an increase in the PDI with C1 and C3 were observed. For zeta potential, a decrease with C1, and an increase with C2 and C3 were found. Concerning the encapsulated AG, a moderate decrease, a strong decrease and a total disappearance were noted with conditions C1, C2 and C3 respectively.

Research Center/Unit :

CESAM - Complex and Entangled Systems from Atoms to Materials - ULiège
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège
CERM - Center for Education and Research on Macromolecules - ULiège

Disciplines :

Materials science & engineering
Chemistry
Pharmacy, pharmacology & toxicology

Author, co-author :

Delma, Kouka Luc ; University Joseph KI-ZERBO, Laboratory of Drug Development, Burkina Faso > University of Liège (ULiège), Laboratory of Pharmaceutical Technology and Biopharmacy, Center for Interdisciplinary Research on Medicines (CIRM), Belgium

Penoy, Noémie ; University of Liège (ULiège), Laboratory of Pharmaceutical Technology and Biopharmacy, Center for Interdisciplinary Research on Medicines (CIRM), Belgium

Grignard, Bruno ; University of Liège (ULiège), Complex and Entangled Systems from Atoms to Materials (CESAM) Research Unit, Center for Education and Research on Macromolecules (CERM), Belgium

Semdé, Rasmané; Laboratory of Drug Development, Doctoral School of Sciences and Health, University Joseph KI-ZERBO, Burkina Faso

Evrard, Brigitte ; University of Liège (ULiège), Laboratory of Pharmaceutical Technology and Biopharmacy, Center for Interdisciplinary Research on Medicines (CIRM), Belgium

Piel, Géraldine ; University of Liège (ULiège), Laboratory of Pharmaceutical Technology and Biopharmacy, Center for Interdisciplinary Research on Medicines (CIRM), Belgium

Language :

English

Title :

Effects of supercritical carbon dioxide under conditions potentially conducive to sterilization on physicochemical characteristics of a liposome formulation containing apigenin

Publication date :

January 2022

Journal title :

Journal of Supercritical Fluids

ISSN :

0896-8446

Publisher :

Elsevier B.V.

Volume :

179

Pages :

105418

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

ARES CCD - Académie de Recherche et d'Enseignement Supérieur. Coopération au Développement

Funding text :

Authors would like to acknowledge the Academy for research and Higher Education-Development Cooperation Committee (ARES-CCD) for the financial support.

Available on ORBi :

since 10 March 2022

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