Effects of supercritical carbon dioxide under conditions potentially conducive to sterilization on physicochemical characteristics of a liposome formulation containing apigenin - 2022
Effects of supercritical carbon dioxide under conditions potentially conducive to sterilization on physicochemical characteristics of a liposome formulation containing apigenin
[en] In this work, the effects of four supercritical carbon dioxide (ScCO2) conditions potentially conductive to sterilization, on physicochemical characteristics of a liposome formulation containing apigenin (AG) were investigated. These conditions were: C1 (ScCO2/70 °C/150 bar/240 min), C2 (ScCO2/0.25% water/ 0.15% H2O2)/ 0.5% acetic anhydride/38 °C/85 bar/45 min), C3 (ScCO2/0.08% peracetic acid/35 °C/104 bar/180 min) and C4 (ScCO2/ 200 ppm H2O2/40 °C/270 bar/90 min). The results showed changes in color and a decrease in pH value of liposomes suspension after treatment with all tested conditions. Moreover, a decrease in liposome size with C1, C2 and C3 and an increase in the PDI with C1 and C3 were observed. For zeta potential, a decrease with C1, and an increase with C2 and C3 were found. Concerning the encapsulated AG, a moderate decrease, a strong decrease and a total disappearance were noted with conditions C1, C2 and C3 respectively.
Research Center/Unit :
CESAM - Complex and Entangled Systems from Atoms to Materials - ULiège CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège CERM - Center for Education and Research on Macromolecules - ULiège
Delma, Kouka Luc ; University Joseph KI-ZERBO, Laboratory of Drug Development, Burkina Faso > University of Liège (ULiège), Laboratory of Pharmaceutical Technology and Biopharmacy, Center for Interdisciplinary Research on Medicines (CIRM), Belgium
Penoy, Noémie ; University of Liège (ULiège), Laboratory of Pharmaceutical Technology and Biopharmacy, Center for Interdisciplinary Research on Medicines (CIRM), Belgium
Grignard, Bruno ; University of Liège (ULiège), Complex and Entangled Systems from Atoms to Materials (CESAM) Research Unit, Center for Education and Research on Macromolecules (CERM), Belgium
Semdé, Rasmané; Laboratory of Drug Development, Doctoral School of Sciences and Health, University Joseph KI-ZERBO, Burkina Faso
Evrard, Brigitte ; University of Liège (ULiège), Laboratory of Pharmaceutical Technology and Biopharmacy, Center for Interdisciplinary Research on Medicines (CIRM), Belgium
Piel, Géraldine ; University of Liège (ULiège), Laboratory of Pharmaceutical Technology and Biopharmacy, Center for Interdisciplinary Research on Medicines (CIRM), Belgium
Language :
English
Title :
Effects of supercritical carbon dioxide under conditions potentially conducive to sterilization on physicochemical characteristics of a liposome formulation containing apigenin
Publication date :
January 2022
Journal title :
Journal of Supercritical Fluids
ISSN :
0896-8446
Publisher :
Elsevier
Volume :
179
Pages :
105418
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
ARES CCD - Académie de Recherche et d'Enseignement Supérieur. Coopération au Développement
Funding text :
Authors would like to acknowledge the Academy for research and Higher Education-Development Cooperation Committee (ARES-CCD) for the financial support.
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