Feeding the upstream development of potential building blocks towards (phosphono)peptide constructs through enabling multifaceted approaches

In the current blooming of peptide therapeutics and considering their huge growth potential in the near future within the Pharma industry, the development of new reliable and efficient methodologies towards their scale-independent preparation is timely. Continuous flow technology holds great potential for the development of such methodologies as an enabling tool with improved performances compared to regular approaches. This PhD dissertation gathers our results for the preparation of (phosphono)peptide constructs and their corresponding a-aminophosphonic acid (Paa) building blocks.