Article (Scientific journals)
Endocrine-disrupting chemicals and their effects on puberty.
Lopez Rodriguez, David; Franssen, Delphine; Heger, Sabine et al.
2021In Best Practice and Research. Clinical Endocrinology and Metabolism, 35 (5), p. 101579
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Keywords :
Endocrine Disruptors; Animals; Endocrine Disruptors/toxicity; Female; Humans; Male; Obesity/chemically induced/epidemiology/genetics; Puberty; Puberty, Precocious/chemically induced/epidemiology/genetics; Sexual Maturation; GnRH; epigenetics; hypothalamus; pubertal timing; secular trend
Abstract :
[en] Sexual maturation in humans is characterized by a unique individual variability. Pubertal onset is a highly heritable polygenic trait but it is also affected by environmental factors such as obesity or endocrine disrupting chemicals. The last 30 years have been marked by a constant secular trend toward earlier age at onset of puberty in girls and boys around the world. More recent data, although more disputed, suggest an increased incidence in idiopathic central precocious puberty. Such trends point to a role for environmental factors in pubertal changes. Animal data suggest that the GnRH-neuronal network is highly sensitive to endocrine disruption during development. This review focuses on the most recent data regarding secular trend in pubertal timing as well as potential new epigenetic mechanisms explaining the developmental and transgenerational effects of endocrine disrupting chemicals on pubertal timing.
Disciplines :
Pediatrics
Endocrinology, metabolism & nutrition
Author, co-author :
Lopez Rodriguez, David ;  Université de Liège - ULiège > GIGA > GIGA Neurosciences - Neuroendocrinology
Franssen, Delphine ;  Université de Liège - ULiège > GIGA > GIGA Neurosciences - Neuroendocrinology
Heger, Sabine;  Children's Hospital Bult, Janusz-Korczak-Allee 12, 30173, Hannover, Germany.
PARENT, Anne-Simone ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pédiatrie
Language :
English
Title :
Endocrine-disrupting chemicals and their effects on puberty.
Publication date :
September 2021
Journal title :
Best Practice and Research. Clinical Endocrinology and Metabolism
eISSN :
1878-1594
Publisher :
Bailliere Tindall And Cassell, Gb
Volume :
35
Issue :
5
Pages :
101579
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright © 2021 Elsevier Ltd. All rights reserved. Epub 2021 Sep 17.
Available on ORBi :
since 22 February 2022

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