Article (Scientific journals)
SK channels are on the move
Seutin, Vincent; Liégeois, Jean-François
2007In British Journal of Pharmacology, 151 (5), p. 568-570
Peer Reviewed verified by ORBi
 

Files


Full Text
Publ48VS.pdf
Publisher postprint (65.38 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
SK channels; drug selectivity; ion channels; pore blockers; ion channel modulators
Abstract :
[en] Small-conductance Ca (2+) activated K+ channels (SK channels) underlie the medium duration after hyperpolarization that follows single or trains of action potentials in many types of neurons. Three subtypes of SK subunits, SK1 (K(Ca)2.1), SK2 (K(Ca)2.2) and SK3 (K(Ca)2.3), have been cloned and are expressed differentially within the central nervous system (CNS). A paper in this issue of BJP reports the discovery of the first example of a positive modulator displaying not only selectivity for SK channels over other channels, but also a subtype selectivity among SK and analogous channels (SK3 > SK2 >> SK1 = IK). Together with other recent progress in the field, this finding enriches the repertoire of tools available to test the hypothesis that SK channels may be targets for future CNS drugs.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Seutin, Vincent ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Pharmacologie
Liégeois, Jean-François ;  Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
Language :
English
Title :
SK channels are on the move
Publication date :
July 2007
Journal title :
British Journal of Pharmacology
ISSN :
0007-1188
Publisher :
Nature Publishing Group, London, United Kingdom
Volume :
151
Issue :
5
Pages :
568-570
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 December 2008

Statistics


Number of views
60 (15 by ULiège)
Number of downloads
5 (1 by ULiège)

Scopus citations®
 
2
Scopus citations®
without self-citations
2
OpenCitations
 
2

Bibliography


Similar publications



Contact ORBi