[en] In a recent report, we confirmed the role of dopamine in the pathophysiology of depression by demonstrating a blunted response of growth hormone (GH) to apomorphine, a selective dopaminergic agonist, in endogenous depressive patients. Few data are available on the possible psychopathological correlates of disturbances in the apomorphine test. In this study, we assessed the relationship between GH response to apomorphine and the Minnesota multiphasic personality inventory (MMPI) scales in a sample of 20 major depressive inpatients. The GH response (area under the curve) after apomorphine injection was positively correlated with the social introversion scale scores (r = 0.56, df = 19, p less than 0.01) and the anxiety scale scores (r = 0.45, df = 19, p = 0.04). These results suggest dopaminergic overactivity in anxious psychopathology rather than in depressive psychopathology. The relationship between the social introversion scale score and the apomorphine test is in agreement with the dopaminergic hypothesis of schizophrenic disorders.
Disciplines :
Psychiatry
Author, co-author :
Pitchot, William ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Hansenne, Michel ; Université de Liège - ULiège > Département des sciences cognitives > Psycho. de la personnalité et des différences individuelles
Moreno, Antonio Gonzalez; Centre Hospitalier Universitaire de Liège - CHU
von Frenckell, Rémy ; Université de Liège - ULiège > Psychiatrie et psychologie médicale
Ansseau, Marc ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Language :
English
Title :
Psychopathological correlates of dopaminergic disturbances in major depression.
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