[en] OBJECTIVE: To compare cellular and humoral immune responses of beef (Belgian White and Blue [BWB]) and dairy (Friesian-Holstein [FH]) cattle to Psoroptes ovis infestation and to determine whether P ovis infestation impaired immune responses to infectious bovine rhinotracheitis virus (IBR) vaccine or an immunogenic protein (keyhole-limpet hemocyanin [KLH]). ANIMALS: 19 BWB and 6 FH 1-year-old calves. PROCEDURE: 2 trials were performed. In each trial, 7 (trial 1) or 6 (trial 2) BWB calves and 3 FH calves were experimentally infested with P ovis and 3 BWB calves were maintained as uninfested controls. Animals were inoculated with KLH and IBR virus vaccine twice; 3 BWB calves in each trial were treated with ivermectin. Serum antibody responses to KLH, IBR virus, and P ovis were measured by use of ELISA. A lymphocyte transformation assay was used to determine nonspecific responses to 3 mitogens and specific lymphocyte reactivity to P ovis antigen. RESULTS: In each trial, 3 BWB and 3 FH calves developed clinical signs of psoroptic mange and mites could be recovered. Infested and control animals developed similar antibody titers to KLH and IBR virus. Antibodies to P ovis were detected early in some infested calves, and this was correlated with a marked cell-mediated immune response. Lymphocyte responsiveness to the 3 mitogens was not significantly different among groups. CONCLUSIONS: In these calves, infestation with P ovis induced a marked humoral and cell-mediated immune response. Immunosuppression was not evident.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Lonneux, J. F.; Université de Liège - ULiège > Faculté de médecine vétérinaire > Parasitology and pathology of parasitic diseases
Nguyen, T. Q.; Université de Liège - ULiège > Faculté de médecine vétérinaire > Parasitology and pathology of parasitic diseases
Hollanders, W.
Denis, M.; Université de Liège - ULiège > Faculté de médecine vétérinaire > Immunology and Vaccinology
Thiry, Etienne ; Université de Liège - ULiège > Faculté de médecine vétérinaire > Virology and Pathology of viral diseases
Pastoret, Paul-Pierre ; Université de Liège - ULiège > Faculté de médecine vétérinaire > Immunology and Vaccinology
Losson, Bertrand ; Université de Liège - ULiège > Faculté de médecine vétérinaire > Parasitology and pathology of parasitic diseases
Language :
English
Title :
Humoral and Cell-Mediated Immune Responses of Beef and Dairy Cattle Experimentally Infested with Psoroptes Ovis
Publication date :
May 1998
Journal title :
American Journal of Veterinary Research
ISSN :
0002-9645
eISSN :
1943-5681
Publisher :
American Veterinary Medical Association, United States - Illinois
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