Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice

[en] Growing amounts of data indicate involvement of the posterior hypothalamus in the regulation of sleep, especially paradoxical sleep (PS). Accordingly, we previously showed that the melanin-concentrating hormone (MCH)-producing neurons of the rat hypothalamus are selectively activated during a PS rebound. In addition, intracerebroventricular infusion of MCH increases total sleep duration, suggesting a new role for MCH in sleep regulation. To determine whether activation of the MCH system promotes sleep, we studied spontaneous sleep and its homeostatic regulation in mice with deletion of the MCH-receptor 1 gene (MCH-R1– ⁄ – vs. MCH-R1+ ⁄ +) and their behavioural response to modafinil, a powerful antinarcoleptic drug. Here, we show that the lack of functional MCH-R1 results in a hypersomniac-like phenotype, both in basal conditions and after total sleep deprivation, compared to wild-type mice. Further, we found that modafinil was less potent at inducing wakefulness in MCH-R1– ⁄ – than in MCH-R1+ ⁄ + mice. We report for the first time that animals with genetically inactivated MCH signaling exhibit altered vigilance state architecture and sleep homeostasis. This study also suggests that the MCH system may modulate central pathways involved in the wake-promoting effect of modafinil

Disciplines :

Neurosciences & behavior

Author, co-author :

Adamantidis, Antoine ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique

Salvert, D.

Goutagny, R.

Lakaye, Bernard ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique

Gervasconi, D.

Grisar, Thierry ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique

Luppi, P. H.

Fort, P.

Language :

English

Title :

Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice

Publication date :

2008

Journal title :

European Journal of Neuroscience

ISSN :

0953-816X

eISSN :

1460-9568

Publisher :

Blackwell Science, Paris, France

Volume :

Issue :

Pages :

1793-800

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 05 November 2009

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