Reference : Damage and functional recovery of the Atlantic cod (Gadus morhua) inner ear hair cell...
Scientific journals : Article
Life sciences : Aquatic sciences & oceanology
Damage and functional recovery of the Atlantic cod (Gadus morhua) inner ear hair cells following local injection of gentamicin
Faucher, Karine mailto [Université de Liège - ULiège > Département des sciences et gestion de l'environnement > Morphologie fonctionnelle et évolutive >]
Aas-Hansen, Øyvind [ > > ]
Damsgård, Borge [ > > ]
Laukli, Einar [ > > ]
Stenklev, Niels-Christian [ > > ]
International Journal of Audiology
Taylor & Francis
Yes (verified by ORBi)
United Kingdom
[en] Fish hearing ; AEP ; SEM ; Gentamicin ; Inner ear hair cells ; Regeneration
[en] This study addresses the ultrastructural and functional
damage and subsequent recovery of the inner ear in the
Atlantic cod following intrasaccular gentamicin injection.
Inner ear damage was assessed using SEM and measurements
of AEP following 250-Hz pure-tone stimuli. Data
from gentamicin-treated fish were compared with control
(no injection) and sham (injection of saline) fish. Control
fish had normal response thresholds associated with welldeveloped
hair cell bundles in their macula sacculi. Sham
fish had higher response thresholds compared with
control fish during the first week post-intervention, but
response thresholds were subsequently normal. Treated
fish displayed significant inner ear damage associated
with an increased average AEP threshold on the third day
following treatment. Thereafter, inner ear tissue displayed
signs of progressive regeneration until it was comparable
to controls from the 14th day. Response thresholds were
similar to those of control fish from the 17th day
following treatment. These observations suggest that the
macula sacculi of Atlantic cod can regenerate towards a
near-complete functional and ultrastructural recovery
within 17-21 days following ototoxic gentamicin treatment.
Researchers ; Professionals ; Students ; General public

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