Article (Scientific journals)
Fulminant Hepatic Failure Induced by Venlafaxine and Trazodone Therapy: A Case Report.
Detry, Olivier; Delwaide, Jean; De Roover, Arnaud et al.
2009In Transplantation Proceedings, 41 (8), p. 3435-3436
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Keywords :
liver transplantation; liver failure; depression
Abstract :
[en] Although acute hepatitis may be a side effect of many medications, most cases are reversible after treatment interruption, and fulminant hepatic failure (FHF) is rare. Venlafaxine and trazodone are 2 popular antidepressant agents. Alteration of liver enzyme levels has been reported as a side effect of these drugs at normal doses. Herein we have reported the case of a 48-year-old woman without any previous history of liver disease, who developed fulminant liver failure after 4 months of venlafaxine and trazodone therapy. She required liver transplantation, a procedure that was successful with full patient recovery. The first 5 years of follow-up were uneventful. This case documented that venlafaxine and trazodone at normal doses can produce severe liver toxicity. Liver tests should be monitored regularly in patients who receive this therapy.
Disciplines :
Endocrinology, metabolism & nutrition
Surgery
Author, co-author :
Detry, Olivier  ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Delwaide, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
De Roover, Arnaud ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Hans, Marie-France ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Delbouille, Michèle ;  Centre Hospitalier Universitaire de Liège - CHU > Rééducation de la parole - HOPITAL DE JOUR
Monard, Josée ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Honore, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Language :
English
Title :
Fulminant Hepatic Failure Induced by Venlafaxine and Trazodone Therapy: A Case Report.
Publication date :
2009
Journal title :
Transplantation Proceedings
ISSN :
0041-1345
eISSN :
1873-2623
Publisher :
Elsevier Science, New York, United States - New York
Volume :
41
Issue :
8
Pages :
3435-3436
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 October 2009

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