Reference : Role of Gas-6 in adipogenesis and nutritionally induced adipose tissue development in...
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Role of Gas-6 in adipogenesis and nutritionally induced adipose tissue development in mice.
Maquoi, Erik mailto [Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Vörös, Gabor [ > > ]
Carmeliet, Peter [ > > ]
Collen, Désiré [ > > ]
Lijnen, Roger [ > > ]
Arteriosclerosis, Thrombosis, and Vascular Biology
Lippincott Williams & Wilkins
Yes (verified by ORBi)
[en] adipogenesis ; obesity ; tyrosine kinase
[en] OBJECTIVE: A potential role of growth arrest-specific gene 6 (Gas-6) in energy storage in adipose tissue was investigated in murine models of obesity. Gas-6 is a ligand for the Axl, C-Mer, and Sky family of tyrosine kinase receptors. METHODS AND RESULTS: Whereas Gas-6, C-Mer, and Sky were expressed in mature murine adipocytes, the expression of Axl was restricted to the stromal-vascular fraction, which includes pre-adipocytes. During the in vitro conversion of adipogenic 3T3-F442A cells into mature adipocytes, the expression of Gas-6 increased in undifferentiated confluent pre-adipocytes during a transient phase of growth arrest. On treatment of these cells with an adipogenic medium, Gas-6 expression decreased sharply, coinciding with expression of early adipocytes markers. This modulation was not observed in the nonadipogenic 3T3-C2 cells. The Gas-6 mRNA level was transiently downregulated during nutritionally induced expansion of adipose tissues in vivo. When kept on a standard diet, no significant difference in either total body weight or weight of gonadal or subcutaneous fat pads was observed between Gas-6 deficient and wild-type mice. On exposure to a high-fat diet, however, Gas-6-deficient mice had significantly less fat mass than their wild-type counterparts. CONCLUSIONS: Gas-6 enhances the accumulation of adipose tissue in diet-induced obese mice.

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