Myocardial Expression of Estrogen Receptor-mRNA Is Associated With Lower Markers of Post-operative Organ Damage in Young Patients With Congenital Cardiac Defect
Endocrinology, metabolism & nutrition Pediatrics Cardiovascular & respiratory systems
Author, co-author :
ROUATBI, Hatem ; Centre Hospitalier Universitaire de Liège - CHU > Département de Pédiatrie > Service de pédiatrie
FARHAT, Nesrine ; Centre Hospitalier Universitaire de Liège - CHU > Département de Pédiatrie > Service de pédiatrie
Heying, Ruth; University Hospital Leuven > Pediatric Cardiology
Vazquez-Jimenez, Jaime; University Hospital Aachen, Germany > Pediatric and Congenital Cardiac Surgery
Parent, Anne-Simone ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie
Seghaye, Marie-Christine ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie cardiologique et pneumologique
Language :
English
Title :
Myocardial Expression of Estrogen Receptor-mRNA Is Associated With Lower Markers of Post-operative Organ Damage in Young Patients With Congenital Cardiac Defect
Blenck CL Harvey PA Reckelhoff JF Leinwand LA. The importance of biological sex and estrogen in rodent models of cardiovascular health and disease. Circ Res. (2016) 118:1294–312. 10.1161/CIRCRESAHA.116.30750927081111
Novella S Pérez-Cremades D Mompeón A Hermenegildo C. Mechanisms underlying the influence of Oestrogen on cardiovascular physiology in women. J Physiol. (2019) 597:4873–86. 10.1113/JP27806331372994
Hodges YK Tung L Yan XD Graham JD Horwitz KB Horwitz LD. Estrogen receptors alpha and beta: prevalence of estrogen receptor beta mRNA in human vascular smooth muscle and transcriptional effects. Circulation. (2000) 101:1792–8. 10.1161/01.cir.101.15.179210769279
Kuiper GG Carlsson B Grandien K Enmark E Häggblad J Nilsson S et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology. (1997) 138:863–70. 10.1210/endo.138.3.49799048584
Knowlton AA Lee AR. Estrogen and the cardiovascular system. Pharmacol Ther. (2012) 135:54–70. 10.1016/j.pharmthera.2012.03.00722484805
Menazza S Murphy E. The expanding complexity of estrogen receptor signaling in the cardiovascular system. Circ Res. (2016) 118:994–1007. 10.1161/CIRCRESAHA.115.30537626838792
Yao Y Chang X Wang D Ma H Wang H Zhang H et al. Roles of ERK1/2 and PI3K/AKT signaling pathways in mitochondria-mediated apoptosis in testes of hypothyroid rats. Toxicol Res. (2018) 7:1214–24. 10.1039/c8tx00122g30542605
Prossnitz ER Barton M. Estrogen biology: new insights into GPER function and clinical opportunities. Mol Cell Endocrinol. (2014) 389:71–83. 10.1016/j.mce.2014.02.00224530924
Fuentes N Silveyra P. Estrogen receptor signaling mechanisms. Adv Protein Chem Struct Biol. (2019) 116:135–70. 10.1016/bs.apcsb.2019.01.00131036290
Crider A Pillai A. Estrogen signaling as a therapeutic target in neurodevelopmental disorders. J Pharmacol Exp Ther. (2017) 360:48–58. 10.1124/jpet.116.23741227789681
Crider A Thakkar R Ahmed AO Pillai A. Dysregulation of estrogen receptor beta (ERβ), aromatase (CYP19A1), and ER co-activators in the middle frontal gyrus of autism spectrum disorder subjects. Mol Autism. (2014) 5:46. 10.1186/2040-2392-5-4625221668
Nordmeyer J Eder S Mahmoodzadeh S Martus P Fielitz J Bass J et al. Upregulation of myocardial estrogen receptors in human aortic stenosis. Circulation. (2004) 110:3270–5. 10.1161/01.CIR.0000147610.41984.E815533858
Rouatbi H Farhat N Heying R Gérard A Vazquez-Jimenez JF Seghaye MC. Right atrial myocardial remodeling in children with atrial septal defect involves inflammation, growth, fibrosis, and apoptosis. Front Pediatr. (2020) 8:40. 10.3389/fped.2020.0004032117843
Qing M Schumacher K Heise R Wöltje M Vazquez-Jimenez JF Richter T et al. Intramyocardial synthesis of pro- and anti-inflammatory cytokines in infants with congenital cardiac defects. J Am Coll Cardiol. (2003) 41:2266–74. 10.1016/s0735-1097(03)00477-712821258
Liersch PN Schwarz A Sachweh J Hermanns-Sachweh B Heying R Vázquez-Jimènez JF et al. Gene expression of cytokines, growth factors and apoptosis regulators in a neonatal model of pulmonary stenosis. Future Cardiol. (2015) 11:297–307. 10.2217/fca.15.2526021636
Mir TS Flato M Falkenberg J Haddad M Budden R Weil J et al. Plasma concentrations of N-terminal brain natriuretic peptide in healthy children, adolescents, and young adults: effect of age and gender. Pediatr Cardiol. (2006) 27:73–7. 10.1007/s00246-005-1022-416132298
Maffei S Del Ry S Prontera C Clerico A. Increase in circulating levels of cardiac natriuretic peptides after hormone replacement therapy in postmenopausal women. Clin Sci. (2001) 101:447–53.11672449
Cunningham M Gilkeson G. Estrogen receptors in immunity and autoimmunity. Clin Rev Allergy Immunol. (2011) 40:66–73. 10.1007/s12016-010-8203-520352526
Tan IJ Peeva E Zandman-Goddard G. Hormonal modulation of the immune system—a spotlight on the role of progestogens. Autoimmun Rev. (2015) 14:536–42. 10.1016/j.autrev.2015.02.00425697984
Straub RH. The complex role of estrogens in inflammation. Endocr Rev. (2007) 28:521–74. 10.1210/er.2007-000117640948
Ito A Bebo BF Jr Matejuk A Zamora A Silverman M Fyfe-Johnson A et al. Estrogen treatment down-regulates TNF-alpha production and reduces the severity of experimental autoimmune encephalomyelitis in cytokine knockout mice. J Immunol. (2001) 167:542–52. 10.4049/jimmunol.167.1.54211418693
Chadwick CC Chippari S Matelan E Borges-Marcucci L Eckert AM Keith JC Jr et al. Identification of pathway-selective estrogen receptor ligands that inhibit NF-kappaB transcriptional activity. Proc Natl Acad Sci USA. (2005) 102:2543–8. 10.1073/pnas.040584110215699342
Galien R Garcia T. Estrogen receptor impairs interleukin-6 expression by preventing protein binding on the NF-kappaB site. Nucleic Acids Res. (1997) 25:2424–9. 10.1093/nar/25.12.24249171095
Kurebayashi S Miyashita Y Hirose T Kasayama S Akira S Kishimoto T. Characterization of mechanisms of interleukin-6 gene repression by estrogen receptor. J Steroid Biochem Mol Biol. (1997) 60:11–7. 10.1016/s0960-0760(96)00175-69182853
McCracken SA Drury CL Lee HS Morris JM. Pregnancy is associated with suppression of the nuclear factor kappaB/IkappaB activation pathway in peripheral blood mononuclear cells. J Reprod Immunol. (2003) 58:27–47. 10.1016/s0165-0378(02)00081-512609523
Messingham KA Heinrich SA Kovacs EJ. Estrogen restores cellular immunity in injured male mice via suppression of interleukin-6 production. J Leukoc Biol. (2001) 70:887–95.11739551
Kovats S. Estrogen receptors regulate innate immune cells and signaling pathways. Cell Immunol. (2015) 294:63–9. 10.1016/j.cellimm.2015.01.01825682174
Zhao L Mao Z Brinton RD. A select combination of clinically relevant phytoestrogens enhances estrogen receptor beta-binding selectivity and neuroprotective activities in vitro and in vivo. Endocrinology. (2009) 150:770–83. 10.1210/en.2008-071518818291
Jankowski M Rachelska G Donghao W McCann SM Gutkowska J. Estrogen receptors activate atrial natriuretic peptide in the rat heart. Proc Natl Acad Sci U S A. (2001) 98:11765–70. 10.1073/pnas.20139419811562484
Schneider CP Nickel EA Samy TS Schwacha MG Cioffi WG Bland KI et al. The aromatase inhibitor, 4-hydroxyandrostenedione, restores immune responses following trauma-hemorrhage in males and decreases mortality from subsequent sepsis. Shock. (2000) 14:347–53. 10.1097/00024382-200014030-0001911028555
Tamir S Izrael S Vaya J. The effect of oxidative stress on ERalpha and ERbeta expression. J Steroid Biochem Mol Biol. (2002) 81:327–32. 10.1016/s0960-0760(02)00115-212361722
Kurebayashi J Otsuki T Moriya T Sonoo H. Hypoxia reduces hormone responsiveness of human breast cancer cells. Jpn J Cancer Res. (2001) 92:1093–101. 10.1111/j.1349-7006.2001.tb01064.x11676860
Frump AL Selej M Wood JA Albrecht M Yakubov B Petrache I et al. Hypoxia upregulates estrogen receptor β in pulmonary artery endothelial cells in a HIF-1α-dependent manner. Am J Respir Cell Mol Biol. (2018) 59:114–26. 10.1165/rcmb.2017-0167OC29394091
Ryu K Park C Lee Y. Hypoxia-inducible factor 1 alpha represses the transcription of the estrogen receptor alpha gene in human breast cancer cells. Biochem Biophys Res Commun. (2011) 407:831–6. 10.1016/j.bbrc.2011.03.11921458421
Qing M Görlach A Schumacher K Wöltje M Vazquez-Jimenez JF Hess J et al. The hypoxia-inducible factor HIF-1 promotes intramyocardial expression of VEGF in infants with congenital cardiac defects. Basic Res Cardiol. (2007) 102:224–32. 10.1007/s00395-007-0639-217268888
Seghaye MC. The clinical implications of the systemic inflammatory reaction related to cardiac operations in children. Cardiol Young. (2003) 13:228–39. 10.1017/s104795110300046512903869
Hövels-Gürich HH Vazquez-Jimenez JF Silvestri A Schumacher K Minkenberg R Duchateau J et al. Production of proinflammatory cytokines and myocardial dysfunction after arterial switch operation in neonates with transposition of the great arteries. J Thorac Cardiovasc Surg. (2002) 124:811–20. 10.1067/mtc.2002.12230812324741
Levy JH Tanaka KA. Inflammatory response to cardiopulmonary bypass. Ann Thorac Surg. (2003) 75:S715–20. 10.1016/s0003-4975(02)04701-x12607717
Franke A Lante W Fackeldey V Becker HP Thode C Kuhlmann WD et al. Proinflammatory and antiinflammatory cytokines after cardiac operation: different cellular sources at different times. Ann Thorac Surg. (2002) 74:363–71. 10.1016/s0003-4975(02)03658-512173814
Christaki E Opal SM Keith JC Jr Kessinian N Palardy JE Parejo NA et al. Estrogen receptor beta agonism increases survival in experimentally induced sepsis and ameliorates the genomic sepsis signature: a pharmacogenomic study. J Infect Dis. (2010) 201:1250–7. 10.1086/65127620205571
Wang M Crisostomo P Wairiuko GM Meldrum DR. Estrogen receptor-alpha mediates acute myocardial protection in females. Am J Physiol Heart Circ Physiol. (2006) 290:H2204–9. 10.1152/ajpheart.01219.200516415070
Ueda K Adachi Y Liu P Fukuma N Takimoto E. Regulatory actions of estrogen receptor signaling in the cardiovascular system. Front Endocrinol. (2020) 10:909. 10.3389/fendo.2019.0090931998238
