Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication.

[en] Biodegradable polymeric microparticles are widely used in drug delivery systems with prolonged-release profiles and/or cell microcarriers. Their fabrication via the oil/water emulsion solvent evaporation technique has normally required emulsifiers in the aqueous phase. The present work aims to evaluate the effectiveness of various polysaccharides, such as chitosan, hyaluronic acid, cellulose, arabinogalactan, guar and their derivatives, as an alternative to synthetic surfactants for polylactide microparticle stabilization during their fabrication. Targeted modification of the biopolymer's chemical structure was also tested as a tool to enhance polysaccharides' emulsifying ability. The transformation of biomacromolecules into a form of nanoparticle via bottom-up or top-down methods and their subsequent application for microparticle fabrication via the Pickering emulsion solvent evaporation technique was useful as a one-step approach towards the preparation of core/shell microparticles. The effect of polysaccharides' chemical structure and the form of their application on the polylactide microparticles' total yield, size distribution and morphology was evaluated. The application of polysaccharides has great potential in terms of the development of green chemistry and the biocompatibility of the formed microparticles, which is especially important in biomedicine application.

Research center :

CEIB - Centre Interfacultaire des Biomatériaux - ULiège

Disciplines :

Materials science & engineering

Author, co-author :

Demina, Tatiana S.

Kilyashova, Liubov A.

Popyrina, Tatiana N.

Svidchenko, Eugenia A.

Bhuniya, Sankarprasad

Akopova, Tatiana A.

Grandfils, Christian ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine

Language :

English

Title :

Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication.

Publication date :

2021

Journal title :

Polymers

ISSN :

2073-4360

Publisher :

MDPI Open Access Publishing, Switzerland

Volume :

Issue :

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 05 February 2022

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