[en] Dermatophytosis is a superficial fungal infection of the keratinized structures of
the host. Since the last decade, this mycosis became an important health concern
due to an increasing prevalence and to the limited number and efficacy of
available treatments. Several experimental models have then been developed in
order to improve knowledge about this infection and to design new therapeutic
strategies. This chapter presents the variety of dermatophytosis experimental
models and their contribution in the understanding of mechanisms used by
dermatophytes to adhere and to invade the host tissue. Their support to study
the establishment of effective antifungal defenses by the host is also summarized.
The usefulness of these models for testing the efficacy of antifungal compounds is
finally discussed.
Disciplines :
Dermatology
Author, co-author :
Faway, Emilie
Thiry, Marc ; Université de Liège - ULiège > Département des sciences de la vie > Biologie cellulaire
Mignon, Bernard ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Mycologie vétérinaire
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