HCG; Implantation; Pregancy; Immunology; Miscarriages; Thyroid function
Abstract :
[en] Human chorionic gonadotropin (hCG) has four major isoforms: classical hCG, hyperglyco- sylated hCG, free β subunit, and sulphated hCG. Classical hCG is the first molecule synthesized by the embryo. Its RNA is transcribed as early as the eight-cell stage and the blastocyst produces the protein before its implantation. This review synthetizes everything currently known on this multi- effect hormone: hCG levels, angiogenetic activity, immunological actions, and effects on miscarriages and thyroid function.
Research center :
Giga-Development and Stem Cells - ULiège GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège
Gridelet, Virginie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Mawet, Marie ; University of Liège > Department of Gynecology & Obstetrics
Nisolle, Michelle ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Geenen, Vincent ; Université de Liège - ULiège > Centre d'immunologie
Language :
English
Title :
Human Chorionic Gonadotropin and Early Embryogenesis: Review
Publication date :
25 January 2022
Journal title :
International Journal of Molecular Sciences
ISSN :
1661-6596
eISSN :
1422-0067
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
