[en] CASE SERIES SUMMARY: This case series describes the neuromuscular blockade (NMB) following 0.15 mg/kg intravenous (IV) cisatracurium administration in 11 cats undergoing ophthalmological surgery and anaesthetised with isoflurane. Anaesthetic records were analysed retrospectively. Neuromuscular function was assessed by a calibrated train-of-four (TOF) monitor. Cats were 73 ± 53 months old, weighed 4 ± 1 kg and were of American Society of Anesthesiologists' physical classification 2. Duration of anaesthesia and surgery were 144 ± 27 and 94 ± 24 mins, respectively. The lowest TOF count was zero in four cats, four in six cats and for one cat the TOF ratio never decreased below 31%. The time of onset was between 1 and 6 mins after the administration of cisatracurium and the mean duration of action was 20.4 ± 10.1 mins. RELEVANCE AND NOVEL INFORMATION: Cisatracurium at a dose of 0.15 mg/kg IV did not consistently induce a TOF count of zero in all cats. The dose used in these cats did not produce any remarkable cardiovascular side effects. Although the NMB was not complete, the dose given was sufficient to produce central eyeball position, which was the goal of the ophthalmic surgeries.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Van Wijnsberghe, Anne-Sophie ; Université de Liège - ULiège > Dépt d'Ens. et de Clinique des animaux de Compagnie (DCC) > Anesthésiologie et réanimation des animaux de compagnie
Ida, Keila K.
Dmitrovic, Petra ; Université de Liège - ULiège > Dépt d'Ens. et de Clinique des animaux de Compagnie (DCC) > Anesthésiologie et réanimation des animaux de compagnie
Tutunaru, Alexandru-Cosmin ; Université de Liège - ULiège > Dépt d'Ens. et de Clinique des animaux de Compagnie (DCC) > Anesthésiologie et réanimation des animaux de compagnie
Sandersen, Charlotte ; Université de Liège - ULiège > Dépt d'Ens. et de Clinique des animaux de Compagnie (DCC) > Anesthésiologie et réanimation des animaux de compagnie
Language :
English
Title :
Neuromuscular blockade effects of cisatracurium in 11 cats undergoing ophthalmological surgery anaesthetised with isoflurane.
Wastila WB Maehr RB Turner GL, et al. Comparative pharmacology of cisatracurium (51w89), atracurium, and five isomers in cats. Anesthesiology 1996; 85: 169–177.
Auer U Mosing M. A clinical study of the effects of rocuronium in isoflurane-anaesthetized cats. Vet Anaesth Analg 2006; 33: 224–228.
Lien C Eikermann M. Neuromuscular physiology and pharmacology. In: Hemmings HC Egan TD (eds). Pharmacology and physiology for anesthesia. 2nd ed. St Louis, MO: Elsevier, 2019, pp 428–454.
Keegan RD. Muscle relaxants and neuromuscular blockade. In: Grimm KA Lamont LA Tranquilli WJ, et al (eds). Veterinary anesthesia and analgesia. 5th ed. Hoboken, NJ: Wiley-Blackwell, 2015, pp 260–276.
Ida KK Van-Wijnsberghe AS Tutunaru A, et al. Onset and duration of cis-atracurium neuromuscular block during fentanyl and lidocaine infusions in isoflurane-anaesthetised dogs. Vet Rec 2020; 187: e33. DOI: 10.1136/vr.105522.
Driessen JJ van Egmond J van der Pol F, et al. Effects of two benzodiazepines and a benzodiazepine antagonist on neuromuscular blockade in the anaesthetizet cat. Arch Int Pharmacodyn Ther 1987; 286: 58–70.
Karima A Shahabeddin M. Xylazine premedication does not modify the onset and duration of cisatracurium blockade in anaesthetized dogs. J Vet Med 2007; 54: 254–256.
Ozcan A Ozcan N Gulec H, et al. Comparison of the effects of fentanyl, remifentanil, and dexmedetomidine on neuromuscular blockade. J Anesth 2012; 26: 196–199.
Braga-Ade F da Silva Braga F, et al. Influence of hypnotics on cisatracurium-induced neuromuscular block. Use of acceleromyograhpy. Braz J Anesthesiol 2013; 63: 249–253.
Kastrup MR Marsico FF Ascoli FO, et al. Neuromuscular blocking properties of atracurium during sevoflurane or propofol anaesthesia in dogs. Vet Anaesth Analg 2005; 32: 222–227.
Ying C Yun-Yu L Kuan-Sheng C, et al. Comparison of the neuromuscular blocking effects of cisatracurium during isoflurane or propofol anesthesia in dogs. Vet Anesth Analg 2020; 47: 454–462.
Flaherty D Auckburally A. Neuromuscular blocking agents. In: Duke-Novakovski T de Vries M Seymour C (eds). BSAVA manual of canine and feline anaesthesia and analgesia. 3rd ed. Gloucester: British Small Animal Veterinary Association, 2016, pp 214–224.
Suzuki T Munakata K Watanabe N, et al. Comparative fading responses induced by mivacurium, cisatracurium, and d-tubocurarine in the evoked muscular compound action potentials of the cat. J Anesth 2003; 17: 98–103.
Dugdale A. Muscle relaxants. In: Dugdale A (ed). Veterinary anaesthesia: principles to practice. Chichester: Wiley-Blackwell, 2010, pp 141–155.
