Neurobiology of the lateral septum: regulation of social behavior.

[en] Social interactions are essential for mammalian life and are regulated by evolutionary conserved neuronal mechanisms. An individual's internal state, experiences, and the nature of the social stimulus are critical for determining apt responses to social situations. The lateral septum (LS) - a structure of the basal forebrain - integrates abundant cortical and subcortical inputs, and projects to multiple downstream regions to generate appropriate behavioral responses. Although incoming cognitive information is indispensable for contextualizing a social stimulus, neuromodulatory information related to the internal state of the organism significantly influences the behavioral outcome as well. This review article provides an overview of the neuroanatomical properties of the LS, and examines its neurochemical (neuropeptidergic and hormonal) signaling, which provide the neuromodulatory information essential for fine-tuning social behavior across the lifespan.

Disciplines :

Life sciences: Multidisciplinary, general & others

Author, co-author :

Menon, Rohit

Süß, Theresa

De Moura Oliveira, Vinicius Elias ; Université de Liège - ULiège > GIGA Neurosciences - Neuroendocrinology

Neumann, Inga D.

Bludau, Anna

Language :

English

Title :

Neurobiology of the lateral septum: regulation of social behavior.

Publication date :

2021

Journal title :

Trends in Neurosciences

ISSN :

0166-2236

Publisher :

Elsevier, Netherlands

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 07 January 2022

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1228 (4 by ULiège)

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