Antifungal Resistance in Dermatophytes: Genetic considerations, Clinical Presentations and Alternative Therapies

SACHELI, Rosalie; HAYETTE, Marie-Pierre

doi:10.3390/jof7110983

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Antifungal Resistance in Dermatophytes: Genetic considerations, Clinical Presentations and Alternative Therapies

SACHELI, Rosalie; HAYETTE, Marie-Pierre

2021 • In Journal of Fungi

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https://hdl.handle.net/2268/265810

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10.3390/jof7110983

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Keywords :

dermatophytes; resistance; terbinafine

Abstract :

[en] Numerous reports describe the emergence of resistance in dermatophytes, especially in T. rubrum and T. mentagrophytes/indotineae strains. We here present a review of the current status of resistance in dermatophytes worldwide. Resistance to terbinafine is mainly discussed, with dif-ferent mutations found in the squalene epoxidase gene also considered. Resistance to azoles is also approached. Clinical presentations caused by resistant dermatophytes are presented, to-gether with alternative therapies that help to better manage these kind of infections.

Disciplines :

Microbiology

Author, co-author :

SACHELI, Rosalie ; Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire CNR

HAYETTE, Marie-Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Unilab > Service de microbiologie clinique

Language :

English

Title :

Antifungal Resistance in Dermatophytes: Genetic considerations, Clinical Presentations and Alternative Therapies

Publication date :

November 2021

Journal title :

Journal of Fungi

eISSN :

2309-608X

Publisher :

MDPI AG, Switzerland

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 07 December 2021

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