Article (Scientific journals)
A reference map of the human binary protein interactome.
Luck, Katja; Kim, Dae-Kyum; Lambourne, Luke et al.
2020In Nature, 580 (7803), p. 402-408
Peer Reviewed verified by ORBi
 

Files


Full Text
Luck et al-HuRI.pdf
Publisher postprint (5.69 MB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Extracellular Space/metabolism; Humans; Organ Specificity; Protein Interaction Mapping; Proteome/metabolism
Abstract :
[en] Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships(1,2). Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration of HuRI with genome(3), transcriptome(4) and proteome(5) data enables cellular function to be studied within most physiological or pathological cellular contexts. We demonstrate the utility of HuRI in identifying the specific subcellular roles of protein-protein interactions. Inferred tissue-specific networks reveal general principles for the formation of cellular context-specific functions and elucidate potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases. HuRI is a systematic proteome-wide reference that links genomic variation to phenotypic outcomes.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Luck, Katja
Kim, Dae-Kyum
Lambourne, Luke
Spirohn, Kerstin
Begg, Bridget E.
Bian, Wenting
Brignall, Ruth
Cafarelli, Tiziana
Campos-Laborie, Francisco J.
CHARLOTEAUX, Benoit ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de génétique
Choi, Dongsic
Coté, Atina G.
Daley, Meaghan
Deimling, Steven
Dricot, Amélie
Gebbia, Marinella
Hardy, Madeleine F.
Kishore, Nishka
Knapp, Jennifer J.
Kovács, István A.
Lemmens, Irma
Mee, Miles W.
Mellor, Joseph C.
Pollis, Carl
Pons, Carles
Richardson, Aaron D.
Schlabach, Sadie
Teeking, Bridget
Yadav, Anupama
Babor, Mariana
Balcha, Dawit
Basha, Omer
Bowman-Colin, Christian
Chin, Suet-Feung
Choi, Soon Gang
Colabella, Claudia
Coppin, Georges
D'Amata, Cassandra
De Ridder, David
De Rouck, Steffi
Duran-Frigola, Miquel
Ennajdaoui, Hanane
Goebels, Florian
Goehring, Liana
Gopal, Anjali
Haddad, Ghazal
Hatchi, Elodie
Helmy, Mohamed
Jacob, Yves
Kassa, Yoseph
Landini, Serena
Li, Roujia
van Lieshout, Natascha
MacWilliams, Andrew
Markey, Dylan
Paulson, Joseph N.
Rangarajan, Sudharshan
Rasla, John
Rayhan, Ashyad
Rolland, Thomas
San-Miguel, Adriana
Shen, Yun
Sheykhkarimli, Dayag
Sheynkman, Gloria M.
Simonovsky, Eyal
Taşan, Murat
Tejeda, Alexander
Tropepe, Vincent
Twizere, Jean-Claude  ;  Université de Liège - ULiège > Molecular Biology of Diseases-Viral Interactomes Network
Wang, Yang
Weatheritt, Robert J.
Weile, Jochen
Xia, Yu
Yang, Xinping
Yeger-Lotem, Esti
Zhong, Quan
Aloy, Patrick
Bader, Gary D.
De Las Rivas, Javier
Gaudet, Suzanne
Hao, Tong
Rak, Janusz
Tavernier, Jan
Hill, David E.
Vidal, Marc
Roth, Frederick P.
Calderwood, Michael A.
More authors (78 more) Less
Language :
English
Title :
A reference map of the human binary protein interactome.
Publication date :
2020
Journal title :
Nature
ISSN :
0028-0836
eISSN :
1476-4687
Publisher :
Nature Publishing Group, London, United Kingdom
Volume :
580
Issue :
7803
Pages :
402-408
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 November 2021

Statistics


Number of views
161 (4 by ULiège)
Number of downloads
235 (2 by ULiège)

Scopus citations®
 
534
Scopus citations®
without self-citations
506
OpenCitations
 
471

Bibliography


Similar publications



Contact ORBi