In vivo exploration of synaptic projections in frontotemporal dementia.

[en] The purpose of this exploratory research is to provide data on synaptopathy in the behavioral variant of frontotemporal dementia (bvFTD). Twelve patients with probable bvFTD were compared to 12 control participants and 12 patients with Alzheimer’s disease (AD). Loss of synaptic projections was assessed with [18F]UCBH-PET. Total distribution volume was obtained with Logan method using carotid artery derived input function. Neuroimages were analyzed with SPM12. Verbal fluency, episodic memory and awareness of cognitive impairment were equally impaired in patients groups. Compared to controls, [18F]UCBH uptake tended to decrease in the right anterior parahippocampal gyrus of bvFTD patients. Loss of synaptic projections was observed in the right hippocampus of AD participants, but there was no significant difference in [18F]UCBH brain uptake between patients groups. Anosognosia for clinical disorder was correlated with synaptic density in the caudate nucleus and the anteromedial prefrontal cortex. This study suggests that synaptopathy in bvFTD targets the temporal social brain and self-referential processes.

Research Center/Unit :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Disciplines :

Neurology

Author, co-author :

Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et revalid. cogn.

Bahri, Mohamed Ali ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Aging & Memory

Plenevaux, Alain ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Preclinical Imaging

Becker, Guillaume ; Université de Liège - ULiège > Département de Psychologie > Département de Psychologie

Seret, Alain ; Université de Liège - ULiège > Département de physique > Imagerie médicale expérimentale

Delhaye, Emma ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Aging & Memory

Degueldre, Christian ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Aging & Memory

Balteau, Evelyne ; Université de Liège - ULiège > GIGA CRC In vivo Im. - Neuroimaging, data acquisi. & proces.

Lemaire, Christian ; Université de Liège - ULiège > CRC In vivo Imaging-Radiochemistry

Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences)

Bastin, Christine ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Aging & Memory

Language :

English

Title :

In vivo exploration of synaptic projections in frontotemporal dementia.

Publication date :

09 August 2021

Journal title :

Scientific Reports

eISSN :

2045-2322

Publisher :

Nature Publishing Group, London, United Kingdom

Volume :

Pages :

16092

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://www.nature.com/articles/s41598-021-95499-1

Funders :

Fondation Recherche Alzheimer
F.R.S.-FNRS - Fonds de la Recherche Scientifique
FRB - Fondation Roi Baudouin
ULiège FSR - Université de Liège. Fonds spéciaux pour la recherche

Funding text :

SAO-FRA

Available on ORBi :

since 09 November 2021

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