Article (Scientific journals)
In vivo exploration of synaptic projections in frontotemporal dementia.
Salmon, Eric; Bahri, Mohamed Ali; Plenevaux, Alain et al.
2021In Scientific Reports, 11, p. 16092
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Keywords :
Alzheimer’s disease; frontotemporal dementia; PET imaging; SV2A; UCB-H
Abstract :
[en] The purpose of this exploratory research is to provide data on synaptopathy in the behavioral variant of frontotemporal dementia (bvFTD). Twelve patients with probable bvFTD were compared to 12 control participants and 12 patients with Alzheimer’s disease (AD). Loss of synaptic projections was assessed with ­[18F]UCBH-PET. Total distribution volume was obtained with Logan method using carotid artery derived input function. Neuroimages were analyzed with SPM12. Verbal fluency, episodic memory and awareness of cognitive impairment were equally impaired in patients groups. Compared to controls, ­[18F]UCBH uptake tended to decrease in the right anterior parahippocampal gyrus of bvFTD patients. Loss of synaptic projections was observed in the right hippocampus of AD participants, but there was no significant difference in ­[18F]UCBH brain uptake between patients groups. Anosognosia for clinical disorder was correlated with synaptic density in the caudate nucleus and the anteromedial prefrontal cortex. This study suggests that synaptopathy in bvFTD targets the temporal social brain and self-referential processes.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Author, co-author :
Salmon, Eric  ;  Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et revalid. cogn.
Bahri, Mohamed Ali  ;  Université de Liège - ULiège > GIGA CRC In vivo Imaging - Aging & Memory
Plenevaux, Alain  ;  Université de Liège - ULiège > GIGA CRC In vivo Imaging - Preclinical Imaging
Becker, Guillaume ;  Université de Liège - ULiège > Département de Psychologie > Département de Psychologie
Seret, Alain ;  Université de Liège - ULiège > Département de physique > Imagerie médicale expérimentale
Delhaye, Emma  ;  Université de Liège - ULiège > GIGA CRC In vivo Imaging - Aging & Memory
Degueldre, Christian ;  Université de Liège - ULiège > GIGA CRC In vivo Imaging - Aging & Memory
Balteau, Evelyne ;  Université de Liège - ULiège > GIGA CRC In vivo Im. - Neuroimaging, data acquisi. & proces.
Lemaire, Christian ;  Université de Liège - ULiège > CRC In vivo Imaging-Radiochemistry
Luxen, André ;  Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences)
Bastin, Christine  ;  Université de Liège - ULiège > GIGA CRC In vivo Imaging - Aging & Memory
Language :
English
Title :
In vivo exploration of synaptic projections in frontotemporal dementia.
Publication date :
09 August 2021
Journal title :
Scientific Reports
eISSN :
2045-2322
Publisher :
Nature Publishing Group, London, United Kingdom
Volume :
11
Pages :
16092
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
SAO-FRA
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
FRB - Fondation Roi Baudouin [BE]
FSR University of Liege
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