B cell-intrinsic MyD88 signaling controls IFN-γ-mediated early IgG2c class switching in mice in response to a particulate adjuvant

Lee, M. S. J.; Natsume-Kitatani, Y.; Temizoz, B.; Fujita, Y.; Konishi, A.; Matsuda, K.; Igari, Y.; Tsukui, T.; Kobiyama, K.; Kuroda, E.; Onishi, M.; Marichal, Thomas; Ise, W.; Inoue, T.; Kurosaki, T.; Mizuguchi, K.; Akira, S.; Ishii, K. J.; Coban, C.

doi:10.1002/eji.201848084

Article (Scientific journals)

B cell-intrinsic MyD88 signaling controls IFN-γ-mediated early IgG2c class switching in mice in response to a particulate adjuvant

Lee, M. S. J.; Natsume-Kitatani, Y.; Temizoz, B. et al.

2019 • In European Journal of Immunology, 49 (9), p. 1433-1440

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/264700

DOI
10.1002/eji.201848084

PubMed
31087643

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Keywords :

B cells; IFN-γ; Myd88 protein, mouse; Article; B lymphocyte; T lymphocyte; C57BL mouse; Adjuvants, Immunologic; Animals; B-Lymphocytes; Dendritic Cells; Immunoglobulin Class Switching; Immunoglobulin G; Interferon-gamma; Killer Cells, Natural; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88; Signal Transduction; T-Lymphocytes

Abstract :

[en] Adjuvants improve the potency of vaccines, but the modes of action (MOAs) of most adjuvants are largely unknown. TLR-dependent and -independent innate immune signaling through the adaptor molecule MyD88 has been shown to be pivotal to the effects of most adjuvants; however, MyD88's involvement in the TLR-independent MOAs of adjuvants is poorly understood. Here, using the T-dependent antigen NIPOVA and a unique particulate adjuvant called synthetic hemozoin (sHZ), we show that MyD88 is required for early GC formation and enhanced antibody class-switch recombination (CSR) in mice. Using cell-type-specific MyD88 KO mice, we found that IgG2c class switching, but not IgG1 class switching, was controlled by B cell-intrinsic MyD88 signaling. Notably, IFN-γ produced by various cells including T cells, NK cells, and dendritic cells was the primary cytokine for IgG2c CSR and B-cell intrinsic MyD88 is required for IFN-γ production. Moreover, IFN-γ receptor (IFNγR) deficiency abolished sHZ-induced IgG2c production, while recombinant IFN-γ administration successfully rescued IgG2c CSR impairment in mice lacking B-cell intrinsic MyD88. Together, our results show that B cell-intrinsic MyD88 signaling is involved in the MOA of certain particulate adjuvants and this may enhance our specific understanding of how adjuvants and vaccines work. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Disciplines :

Life sciences: Multidisciplinary, general & others

Author, co-author :

Lee, M. S. J.; Laboratory of Malaria Immunology, Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan

Natsume-Kitatani, Y.; Laboratory of Bioinformatics, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka, Japan

Temizoz, B.; Laboratory of Vaccine Science, Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan

Fujita, Y.; Laboratory of Malaria Immunology, Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan

Konishi, A.; Laboratory of Malaria Immunology, Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan

Matsuda, K.; Laboratory of Malaria Immunology, Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan

Igari, Y.; ZENOAQ, Nippon Zenyaku Kogyo Co. Ltd., Koriyama, Fukushima, Japan

Tsukui, T.; ZENOAQ, Nippon Zenyaku Kogyo Co. Ltd., Koriyama, Fukushima, Japan

Kobiyama, K.; Laboratory of Vaccine Science, Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan, Laboratory of Adjuvant Innovation, National Institutes of Biomedical Innovation Health and Nutrition (NIBIOHN), Osaka, Japan

Kuroda, E.; Laboratory of Vaccine Science, Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan, Laboratory of Adjuvant Innovation, National Institutes of Biomedical Innovation Health and Nutrition (NIBIOHN), Osaka, Japan

More authors (9 more)

Language :

English

Title :

B cell-intrinsic MyD88 signaling controls IFN-γ-mediated early IgG2c class switching in mice in response to a particulate adjuvant

Publication date :

2019

Journal title :

European Journal of Immunology

ISSN :

0014-2980

eISSN :

1521-4141

Publisher :

Wiley-VCH Verlag

Volume :

Issue :

Pages :

1433-1440

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

Japan Agency for Medical Research and Development, AMED: 16H05181, AMED 16ak0101010h0005, AMED J-PRIDE 17fm0208021h0001

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