Article (Scientific journals)
New insights on the PBMCs phospholipidome in obesity demonstrate modulations associated with insulin resistance and glycemic status
Wilkin, Chloé; Colonval, Megan; Dehairs, Jonas et al.
2021In Nutrients
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Keywords :
Lipidomic; Obesity; Metabolism
Abstract :
[en] Abstract: (1) Background: Obesity and type 2 diabetes have been suspected to impact both intrin-sic metabolism and function of circulating immune cells. (2) Methods: To further investigate this immunometabolic modulation, we profiled the phospholipidome of the peripheral blood mononu-clear cells (PBMCs) in lean, normoglycemic obese (OBNG) and obese with dysglycemia (OBDysG) individuals. (3) Results: The global PBMCs phospholipidome is significantly downmodulated in OBDysG unlike OBNG patients when compared to lean ones. Multiple linear regression analyses show a strong negative relationship between the global PBMCs phospholipidome and parameters assessing insulin resistance. Even though all classes of phospholipid are affected, the relative abundance of each class is maintained with the exception of Lyso-PC/PC and Lyso-PE/PE ratios that are downmodulated in PBMCs of OBDysG compared to OBNG individuals. Interestingly, the percentage of saturated PC is positively associated with glycated hemoglobin (HbA1c). Moreover, a few lipid species are significantly downmodulated in PBMCs of OBDysG compared to OBNG individuals, making possible to distinguish the two phenotypes. (4) Conclusions: This lipidomic study highlights for the first-time modulations of the PBMCs phospholipidome in obese patients with prediabetes and type 2 diabetes. Such phospholipidome remodeling could disrupt the cell membranes and the lipid mediator’s levels, driving an immune cell dysfunction.
Research center :
GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Wilkin, Chloé  ;  Université de Liège - ULiège > GIGA I3 - Immunometabolism and Nutrition
Colonval, Megan;  Université de Liège - ULiège > GIGA I3 - Immunometabolism and Nutrition
Dehairs, Jonas;  KU Leuven > Department of Oncology > Laboratory of Lipid Metabolism and Cancer
Esser, Nathalie  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de diabétologie, nutrition, maladies métaboliques
Iovino, Margaud ;  Université de Liège - ULiège > GIGA I3 - Immunometabolism and Nutrition
Gianfrancesco, Marco A.;  Université de Liège - ULiège > GIGA I3 - Immunometabolism and Nutrition
FADEUR, Marjorie ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de diabétologie, nutrition, maladies métaboliques
Swinnen, Johan V.;  KU Leuven > Department of Oncology > Laboratory of Lipid Metabolism and Cancer
PAQUOT, Nicolas ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de diabétologie, nutrition, maladies métaboliques
Piette, Jacques ;  Université de Liège - ULiège > GIGA I3 - Virology and Immunology
Legrand, Sylvie ;  Université de Liège - ULiège > GIGA I3 - Immunometabolism and Nutrition
Language :
English
Title :
New insights on the PBMCs phospholipidome in obesity demonstrate modulations associated with insulin resistance and glycemic status
Publication date :
29 September 2021
Journal title :
Nutrients
ISSN :
2072-6643
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Fonds Léon Fredericq [BE]
Interuniversity Attraction Poles program
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