Article (Scientific journals)
Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity.
Butera, Yvan; Mukantwari, Enatha; Artesi, Maria et al.
2021In Nature Communications, 12 (1), p. 5705
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Keywords :
Adult; COVID-19/diagnosis/epidemiology/transmission/virology; Epidemiological Monitoring; Female; Genome, Viral/genetics; Humans; Male; Phylogeny; Phylogeography; RNA, Viral/genetics/isolation & purification; Rwanda/epidemiology; SARS-CoV-2/genetics/isolation & purification/pathogenicity; Travel-Related Illness; Whole Genome Sequencing
Abstract :
[en] COVID-19 transmission rates are often linked to locally circulating strains of SARS-CoV-2. Here we describe 203 SARS-CoV-2 whole genome sequences analyzed from strains circulating in Rwanda from May 2020 to February 2021. In particular, we report a shift in variant distribution towards the emerging sub-lineage A.23.1 that is currently dominating. Furthermore, we report the detection of the first Rwandan cases of the B.1.1.7 and B.1.351 variants of concern among incoming travelers tested at Kigali International Airport. To assess the importance of viral introductions from neighboring countries and local transmission, we exploit available individual travel history metadata to inform spatio-temporal phylogeographic inference, enabling us to take into account infections from unsampled locations. We uncover an important role of neighboring countries in seeding introductions into Rwanda, including those from which no genomic sequences were available. Our results highlight the importance of systematic genomic surveillance and regional collaborations for a durable response towards combating COVID-19.
Disciplines :
Microbiology
Author, co-author :
Butera, Yvan  
Mukantwari, Enatha
Artesi, Maria ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Génétique humaine
Umuringa, Jeanne D Arc
O'Toole, Áine Niamh
Hill, Verity
Rooke, Stefan
Hong, Samuel Leandro
Dellicour, Simon
Majyambere, Onesphore
Bontems, Sébastien ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Bact., mycologie, parasitologie, virologie, microbio.
Boujemla, Bouchra ;  Université de Liège - ULiège > GIGA Cancer - Human Genetics
Quick, Josh
Resende, Paola Cristina
Loman, Nick
Umumararungu, Esperance
Kabanda, Alice
Murindahabi, Marylin Milumbu
Tuyisenge, Patrick
Gashegu, Misbah
Rwabihama, Jean Paul
Sindayiheba, Reuben
Gikic, Djordje
Souopgui, Jacob
Ndifon, Wilfred
Rutayisire, Robert
Gatare, Swaibu
Mpunga, Tharcisse
Ngamije, Daniel
Bours, Vincent ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Génétique humaine
Rambaut, Andrew
Nsanzimana, Sabin
Baele, Guy 
Durkin, Keith   ;  Université de Liège - ULiège > GIGA Cancer - Human Genetics
Mutesa, Leon 
Rujeni, Nadine 
More authors (26 more) Less
 These authors have contributed equally to this work.
Language :
English
Title :
Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity.
Publication date :
2021
Journal title :
Nature Communications
eISSN :
2041-1723
Publisher :
Nature Publishing Group, United Kingdom
Volume :
12
Issue :
1
Pages :
5705
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
© 2021. The Author(s).
Available on ORBi :
since 22 October 2021

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