Article (Scientific journals)
Inhibiteurs des SGLT2: focus sur le rein et la néphroprotection.
Scheen, André; Delanaye, Pierre
2021In Revue Médicale Suisse, 17 (747), p. 1397-1403
Peer Reviewed verified by ORBi
 

Files


Full Text
2021 RMS delanaye Scheen nephroprotection .pdf
Publisher postprint (6.72 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Diabetes Mellitus, Type 2/complications/drug therapy; Diabetic Nephropathies/drug therapy/prevention & control; Glomerular Filtration Rate; Humans; Kidney; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
Abstract :
[en] The relationships between sodium-glucose cotransporter type 2 inhibitors (SGLT2is) and kidney are complex: reduction of the glucose-lowering effect with the decline of glomerular filtration rate (GFR), biphasic effects on GFR along with treatment duration, low risk of acute kidney injury, rapid reduction of albuminuria, and, most importantly in clinical practice, a remarkable nephroprotection, with a decrease of the risk of end-stage renal disease or death from renal cause. This article describes the renal outcomes in the main clinical trials and analyses the impact of treatment with SGLT2is on renal prognosis according to different patient baseline characteristics. A nephroprotection is observed whatever the severity (even if GFR < 45 ml/min/1,73 m²) and type (with or without albuminuria, with or without diabetes) of renal disease.
Disciplines :
Urology & nephrology
Pharmacy, pharmacology & toxicology
Author, co-author :
Scheen, André   ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Delanaye, Pierre   
 These authors have contributed equally to this work.
Language :
French
Title :
Inhibiteurs des SGLT2: focus sur le rein et la néphroprotection.
Alternative titles :
[en] SGLT2 inhibitors: focus on kidneys and nephroprotection
Publication date :
2021
Journal title :
Revue Médicale Suisse
ISSN :
1660-9379
Publisher :
Medecine et Hygiène, Switzerland
Volume :
17
Issue :
747
Pages :
1397-1403
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 October 2021

Statistics


Number of views
81 (9 by ULiège)
Number of downloads
11 (8 by ULiège)

Scopus citations®
 
2
Scopus citations®
without self-citations
0

Bibliography


Similar publications



Contact ORBi