Polycystic ovarian syndrome and infertility: overview and insights of the putative treatments.

[en] Infertility concerns 15% of the couples. Management of female infertility requires a complete history of the patient followed by a physical, gynecological and endocrine examination. Infertility etiology will be investigated thanks to different tests including ovarian function and reserve assessment, search for uterine abnormalities and evaluation of tubal permeability. Polycystic ovarian syndrome (PCOS) is a predominant cause of infertility and a common gyne-endocrine disorder affecting 7 to 15% of women in reproductive age. Behavioral, medical and surgical treatments have been evaluated in order to improve the fertility of women with PCOS. Lifestyle modifications (stop smoking, physical exercise and weight loss when necessary) are of the utmost importance. Clomiphene citrate remains the first line of medical treatment of infertility in women with PCOS in absence of other male or female causes of infertility. Use of metformin solely for infertility is not recommended in absence of metabolic anomaly and new treatment as myoinositol is emerging. Surgical techniques aiming to enhance ovulation and pregnancy rate are an option when medical treatment failed. Ovarian drilling by laparoscopy or by transvaginal hydrolaparoscopy is taking a larger place in the treatment of infertility. In vitro maturation and fertilization remain the third-line of treatment in PCOS.

Disciplines :

Reproductive medicine (gynecology, andrology, obstetrics)

Author, co-author :

Collée, Julie

Mawet, Marie

Tebache, Linda

Nisolle, Michelle ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique

Brichant, Géraldine ; Centre Hospitalier Universitaire de Liège - CHU > Département de gynécologie-obstétrique > Service de gynécologie-obstétrique (CHR)

Language :

English

Title :

Polycystic ovarian syndrome and infertility: overview and insights of the putative treatments.

Publication date :

2021

Journal title :

Gynecological Endocrinology

ISSN :

0951-3590

eISSN :

1473-0766

Volume :

Issue :

Pages :

869-874

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 06 October 2021

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