Article (Scientific journals)
Polycystic ovarian syndrome and infertility: overview and insights of the putative treatments.
Collée, Julie; Mawet, Marie; Tebache, Linda et al.
2021In Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 37 (10), p. 869-874
Peer reviewed
 

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Keywords :
Polycystic ovary syndrome; infertility; medical treatment; ovarian drilling
Abstract :
[en] Infertility concerns 15% of the couples. Management of female infertility requires a complete history of the patient followed by a physical, gynecological and endocrine examination. Infertility etiology will be investigated thanks to different tests including ovarian function and reserve assessment, search for uterine abnormalities and evaluation of tubal permeability. Polycystic ovarian syndrome (PCOS) is a predominant cause of infertility and a common gyne-endocrine disorder affecting 7 to 15% of women in reproductive age. Behavioral, medical and surgical treatments have been evaluated in order to improve the fertility of women with PCOS. Lifestyle modifications (stop smoking, physical exercise and weight loss when necessary) are of the utmost importance. Clomiphene citrate remains the first line of medical treatment of infertility in women with PCOS in absence of other male or female causes of infertility. Use of metformin solely for infertility is not recommended in absence of metabolic anomaly and new treatment as myoinositol is emerging. Surgical techniques aiming to enhance ovulation and pregnancy rate are an option when medical treatment failed. Ovarian drilling by laparoscopy or by transvaginal hydrolaparoscopy is taking a larger place in the treatment of infertility. In vitro maturation and fertilization remain the third-line of treatment in PCOS.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Collée, Julie  
Mawet, Marie
Tebache, Linda 
Nisolle, Michelle ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Brichant, Géraldine ;  Centre Hospitalier Universitaire de Liège - CHU > Département de gynécologie-obstétrique > Service de gynécologie-obstétrique (CHR)
Language :
English
Title :
Polycystic ovarian syndrome and infertility: overview and insights of the putative treatments.
Publication date :
2021
Journal title :
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
ISSN :
0951-3590
eISSN :
1473-0766
Volume :
37
Issue :
10
Pages :
869-874
Peer reviewed :
Peer reviewed
Available on ORBi :
since 06 October 2021

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