antihypertension; gastrointestinal digestion; ACE inhibitory peptides; gut dysbiosis; microbiota modification
Abstract :
[en] Despite the well-established role of quinoa protein as the source of antihypertensive
peptides through in vitro enzymolysis, there is little evidence supporting the in vivo antihypertensive effect of intact quinoa protein. In this study, in vivo study on spontaneously hypertensive rats (SHRs) was conducted by administering quinoa protein for five weeks. Gastrointestinal content identification indicated that many promising precursors of bioactive peptides were released from quinoa protein under gastrointestinal processing. Quinoa protein administration on SHRs resulted in a significant decrease in blood pressure, a significant increase in alpha diversity, and microbial structure alternation towards that in non-hypertension rats. Furthermore, blood pressure was highly negatively correlated with the elevated abundance of genera in quinoa protein-treated SHRs, such as Turicibacter and Allobaculum. Interestingly, the fecal microbiota in quinoa protein-treated SHRs shared more features in the composition of genera with non-hypertension rats than that of the captopril-treated group. These results indicate that quinoa protein may serve as a potential candidate to lower blood pressure and ameliorate hypertension-related gut dysbiosis.
Disciplines :
Agriculture & agronomy
Author, co-author :
Guo, Huimin ; Université de Liège - ULiège > TERRA Research Centre
Hao, Yuqiong
Fan, Xin
Richel, Aurore ; Université de Liège - ULiège > Département GxABT > SMARTECH
Everaert, Nadia ; Université de Liège - ULiège > Département GxABT > Ingénierie des productions animales et nutrition
Yang, Xiushi
Ren, Guixing
Language :
English
Title :
Administration with Quinoa Protein Reduces the Blood Pressure in Spontaneously Hypertensive Rats and Modifies the Fecal Microbiota
Alternative titles :
[en] 比利时
Publication date :
2021
Journal title :
Nutrients
ISSN :
2072-6643
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
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