Article (Scientific journals)
Abnormal vascular architecture at the placental-maternal interface in preeclampsia
Tack, Justine; Munaut, Carine; Blacher, Silvia et al.
2020In European Gynecology and Obstetrics, 2 (1), p. 42-46
Peer reviewed
 

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Keywords :
Preeclampsia; placental bed; vessel architecture; virtual imaging
Abstract :
[en] Background and purpose: The aim of this study was to characterize the vascular architecture in the placental bed in pregnancies complicated by preeclampsia and in normal pregnancies. Methods: Vessel numbers and cross-section area density in 11 preeclamptic placental beds were compared with 10 normal placental beds using computer-assisted image analysis of whole-slide CD31-immunolabeled sections. Results: The total surface occupied by vessels was significantly reduced in preeclamptic placental beds compared with controls beds. However, the number of vessels/section and average surface were similar in all cases. Vessel size distribution differed between the two groups: more smaller vessels were found in preeclamptic placental beds. Conclusions: Using a whole slide scanning and computer-assisted analysis method, we demonstrated a different morphological architecture of vessels in the placental beds of preeclamptic patients which might reflect the previously reported findings of insufficient trophoblast invasion and incomplete vascular remodeling.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Tack, Justine ;  Centre Hospitalier Universitaire de Liège - CHU > Département de gynécologie-obstétrique > Service de gynécologie-obstétrique (CHR)
Munaut, Carine  ;  Université de Liège - ULiège > GIGA Cancer - Tumours and development biology
Blacher, Silvia ;  Université de Liège - ULiège > GIGA Cancer - Tumours and development biology
Noël, Agnès ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire
Nisolle, Michelle ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
CHANTRAINE, Frédéric  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de gynécologie-obstétrique > Secteur obstétrique
Language :
English
Title :
Abnormal vascular architecture at the placental-maternal interface in preeclampsia
Publication date :
2020
Journal title :
European Gynecology and Obstetrics
Volume :
2
Issue :
1
Pages :
42-46
Peer reviewed :
Peer reviewed
Available on ORBi :
since 26 September 2021

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