Efficacy and safety of tianeptine in the treatment of depressive disorders in comparison with fluoxetine

Lôo, H.; Saiz-Ruiz, J.; Costa E Silva, J. A.; ANSSEAU, Marc; Herrington, R.; Vaz-Serra, A.; Dilling, H.; De Risio, S.

doi:10.1002/hup.268

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Efficacy and safety of tianeptine in the treatment of depressive disorders in comparison with fluoxetine

Lôo, H.; Saiz-Ruiz, J.; Costa E Silva, J. A. et al.

2001 • In Human Psychopharmacology, 16 (Suppl. 1), p. 31-S38

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https://hdl.handle.net/2268/262829

DOI
10.1002/hup.268

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Keywords :

Depressive disorders; Fluoxetine; Tianeptine

Abstract :

[en] Depression is treated by a great variety of antidepressant treatments. SSRIs (such as fluoxetine) are well known: it is, however, sure that further progress is needed and the search for antidepressants with other mechanisms of action (such as tianeptine) or different efficacy is still of interest. A multinational study compared tianeptine with fluoxetine in 387 patients with Depressive Episode, or Recurrent Depressive Disorder, or Bipolar Affective Disorder (ICD-10), in a double-blind parallel group design. They were treated for six weeks. At inclusion, no significant difference between groups was shown. Final MADRS scores were 15.7 and 15.8 with tianeptine and fluoxetine, respectively (ITT population) (p = 0.944). MADRS responders were 58% and 56% with tianeptine and fluoxetine, respectively (p = 0.710). No statistical difference was observed for the other efficacy parameters. Thirty-six withdrawals occurred in each group, without any difference for the reasons of discontinuation. There was no major difference between groups for the other safety parameters. In this study, both tianeptine and fluoxetine exhibited a good efficacy and safety.

Disciplines :

Treatment & clinical psychology

Author, co-author :

Lôo, H.; Service Hospitalo-universitaire, Santé Mentale et de Thérapeutique, Sainte-Anne Hospital, Paris Cedex 14, France

Saiz-Ruiz, J.; Ramon Y Cajal Hospital, Department of Psychiatry, Madrid, Spain

Costa E Silva, J. A.; University Hospital, Faculty of Medicine, Rio de Janeiro, Brazil

ANSSEAU, Marc ; Université de Liège - ULg

Herrington, R.; Gartnavel Royal Hospital, Glasgow, United Kingdom

Vaz-Serra, A.; University Hospital, Department of Psychiatry, Coimbra, Portugal

Dilling, H.; University Hospital, Clinic of Psychiatry, Lübeck, Germany

De Risio, S.; Catholic University del Sacro Cuore, Institute of Psychiatry and Psychology, Rome, Italy

Language :

English

Title :

Efficacy and safety of tianeptine in the treatment of depressive disorders in comparison with fluoxetine

Publication date :

2001

Journal title :

Human Psychopharmacology

ISSN :

0885-6222

eISSN :

1099-1077

Publisher :

John Wiley & Sons, Hoboken, United States - New Jersey

Volume :

Issue :

Suppl. 1

Pages :

S31-S38

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 30 August 2021

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