Article (Scientific journals)
Effect of Coxsackievirus B4 Infection on the Thymus: Elucidating Its Role in the Pathogenesis of Type 1 Diabetes
Alhazmi, abdelaziz; Nekoua, Magloire-Pandou; Michaux, Hélène et al.
2021In Microorganisms
Peer Reviewed verified by ORBi
 

Files


Full Text
microorganisms-09-01177.pdf
Publisher postprint (1.67 MB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Viruses; Enterovirus; Coxsackie B; Thymus; Self-tolerance; Autoimmunity; Type 1 diabetes; Fetal and perinatal life
Abstract :
[en] The thymus gland is a primary lymphoid organ for T-cell development. Various viral infections can result in disturbance of thymic functions. Medullary thymic epithelial cells (mTECs) are important for the negative selection of self-reactive T-cells to ensure central tolerance. Insulin-like growth factor 2 (IGF2) is the dominant self-peptide of the insulin family expressed in mTECs and plays a crucial role in the intra-thymic programing of central tolerance to insulin-secreting islet β-cells. Coxsackievirus B4 (CVB4) can infect and persist in the thymus of humans and mice, thus hampering the T-cell maturation and differentiation process. The modulation of IGF2 expression and protein synthesis during a CVB4 infection has been observed in vitro and in vivo in mouse models. The effect of CVB4 infections on human and mouse fetal thymus has been studied in vitro. Moreover, following the inoculation of CVB4 in pregnant mice, the thymic function in the fetus and offspring was disturbed. A defect in the intra-thymic expression of self-peptides by mTECs may be triggered by CVB4. The effects of viral infections, especially CVB4 infection, on thymic cells and functions and their possible role in the pathogenesis of type 1 diabetes (T1D) are presented.
Research center :
GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège
Disciplines :
Immunology & infectious disease
Endocrinology, metabolism & nutrition
Author, co-author :
Alhazmi, abdelaziz;  Univdersité de Lille > Laboratoire de Virologie ULR3610
Nekoua, Magloire-Pandou;  Université de Lille > Laboratoire de Virologie ULR3610
Michaux, Hélène;  Université de Liège - ULiège > GIGA-I3 Neuroimmunoendocrinologie
Sane, Famara;  CHRU Lille > Laboratoire de Virologie ULR3610
Halouani, Aymen;  Université de Monastir > LR99ES27
Engelmann, Ilka;  CHRU Lille > Laboratoire de Virologie ULR3610
Alidjinou, Enagon Kayla;  CHRU Lille > Laboratoire de Virologie ULR3610
Martens, Henri ;  Université de Liège - ULiège > GIGA I3 - Immunoendocrinology
Jaïdane, Hela;  Université de Monastir > LR99ES27
Geenen, Vincent ;  Université de Liège - ULiège > Centre d'immunologie
Hober, Didier;  Université de Lille > Laboratoire de Virologie ULR3610
Language :
English
Title :
Effect of Coxsackievirus B4 Infection on the Thymus: Elucidating Its Role in the Pathogenesis of Type 1 Diabetes
Publication date :
21 May 2021
Journal title :
Microorganisms
eISSN :
2076-2607
Publisher :
Molecular Diversity Preservation International (MDPI), Basel, Switzerland
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 July 2021

Statistics


Number of views
132 (7 by ULiège)
Number of downloads
109 (1 by ULiège)

Scopus citations®
 
11
Scopus citations®
without self-citations
6
OpenCitations
 
7

Bibliography


Similar publications



Contact ORBi