Reference : Parkinson’s disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quanti...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/262176
Parkinson’s disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI
English
[fr] Imagerie multimodale dans la maladie de Parkinson: PET FDOPA, IRM quantitative sensible au fer et à la neuromélanine
DEPIERREUX, Frédérique mailto [Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de neurologie >]
PARMENTIER, Eric mailto [Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de neurologie >]
MACKELS, Laurane mailto [> >]
Baquero Duarte, Katherine Andrea mailto [Université de Liège - ULiège > > GIGA >]
Degueldre, Christian mailto [Université de Liège - ULiège > > GIGA CRC In vivo Imaging - Aging & Memory >]
Balteau, Evelyne mailto [Université de Liège - ULiège > > GIGA CRC In vivo Im. - Neuroimaging, data acquisi. & proces. >]
SALMON, Eric mailto [Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Centre de jour interdisciplinaire des troubles de la mémoire >]
Phillips, Christophe mailto [Université de Liège - ULiège > > GIGA CRC In vivo Im. - Neuroimaging, data acquisi. & proces. >]
Bahri, Mohamed Ali mailto [Université de Liège - ULiège > > GIGA CRC In vivo Imaging - Aging & Memory >]
MAQUET, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de neurologie >]
GARRAUX, Gaëtan mailto [Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Groupe des mouvements anormaux (Movere) >]
8-Jul-2021
NPJ Parkinson's Disease
Nature Publishing Group
1-10
Yes (verified by ORBi)
International
2373-8057
New-York
NY
[en] Parkinson’s disease ; quantitative magnetic resonance imaging ; positron emission tomography ; [18F]-DOPA ; brain iron ; neuromelanin
[en] Parkinson’s disease is a neurodegenerative synucleinopathy characterized by the degeneration of neuromelanin-containing dopaminergic neurons and deposition of iron in the substantia nigra (SN). How regional neuromelanin (NM) loss and iron accumulation within specific areas of SN relates to nigro-striatal dysfunction needs to be clarified. We measured dopaminergic function in pre- and post-commissural putamen by [18F]DOPA PET in twenty-three Parkinson’s disease (PD) patients and 23 healthy control (HC) participants in whom NM content and iron load was assessed in medial and lateral SN, respectively by neuromelanin-sensitive and quantitative R2* MRI. Data analysis consisted of voxelwise regressions testing the group effect and its interaction with NM or iron signals. In PD patients, R2* was selectively increased in left lateral SN as compared to healthy participants, suggesting a local accumulation of iron in Parkinson’s disease. By contrast, NM signal differed between PD and HC, without specific regional specificity within SN. Dopaminergic function in posterior putamen decreased as R2* increased in lateral SN, indicating that dopaminergic function impairment progresses with iron accumulation in the SN. Dopaminergic function was also positively correlated with NM signal in lateral SN, indicating that dopaminergic function impairment progresses with depigmentation in the SN. A complex relationship was detected between R2* in the lateral SN and NM signal in the medial substantia nigra. In conclusion, multimodal imaging reveals regionally-specific relationships between iron accumulation and depigmentation within the SN of Parkinson’s disease and provides in vivo insights in its neuropathology.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique - F.R.S.-FNRS; Fonds Rahier
Parkinson's disease multimodal imaging
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/262176
10.1038/s41531-021-00199-2

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