Imaging lipids in biological samples with surface-assisted laser desorption/ionization mass spectrometry: A concise review of the last decade

Müller, Wendy; De Pauw, Edwin; Far, Johann; Malherbe, Cédric; Eppe, Gauthier

doi:10.1016/j.plipres.2021.101114

Article (Scientific journals)

Imaging lipids in biological samples with surface-assisted laser desorption/ionization mass spectrometry: A concise review of the last decade

Müller, Wendy; De Pauw, Edwin; Far, Johann et al.

2021 • In Progress in Lipid Research, 83 (101114)

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/261772

DOI
10.1016/j.plipres.2021.101114

PubMed
34217733

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Keywords :

Lipidomics; Lipids; Mass spectrometry imaging; SALDI; Biological tissues

Abstract :

[en] Knowing the spatial location of the lipid species present in biological samples is of paramount importance for the elucidation of pathological and physiological processes. In this context, mass spectrometry imaging (MSI) has emerged as a powerful technology allowing the visualization of the spatial distributions of biomolecules, including lipids, in complex biological samples. Among the different ionization methods available, the emerging surface-assisted laser desorption/ionization (SALDI) MSI offers unique capabilities for the study of lipids. This review describes the specific advantages of SALDI-MSI for lipid analysis, including the ability to perform analyses in both ionization modes with the same nanosubstrate, the detection of lipids characterized by low ionization efficiency in MALDI-MS, and the possibilities of surface modification to improve the detection of lipids. The complementarity of SALDI and MALDI-MSI is also discussed. Finally, this review presents data processing strategies applied in SALDI-MSI of lipids, as well as examples of applications of SALDI-MSI in biomedical lipidomics.

Research center :

MolSys - Molecular Systems - ULiège

Disciplines :

Chemistry

Author, co-author :

Müller, Wendy ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique

De Pauw, Edwin ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique

Far, Johann ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique

Malherbe, Cédric ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique

Eppe, Gauthier ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique

Language :

English

Title :

Imaging lipids in biological samples with surface-assisted laser desorption/ionization mass spectrometry: A concise review of the last decade

Publication date :

02 July 2021

Journal title :

Progress in Lipid Research

ISSN :

0163-7827

Publisher :

Elsevier, United Kingdom

Volume :

Issue :

101114

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]

Available on ORBi :

since 05 July 2021

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