Cherubism; Giant Cell Central Granuloma; Association; Imaging; Children
Abstract :
[en] We present an association between non familial cherubism and giant cell central granuloma (GCCG). Cherubism is rare, approximately 300 cases are published, but the non familial form is exceptional. It is a non neoplastic inherited autosomal dominant trait gene mapped to chromosome 4 p 16.3. Location of cherubism is always bilateral, at mandibular angles, sometimes associated with maxillary involvement.
GCCG is a reactive or an inflammatory lesion located anteriorly to the first molar, but exceptionally at mandibular angles.
To the best of our knowledge, presented association is one of the first descriptions with histologic and genetic confirmation.
Orthopantomograms, computed tomography (CT) and Cone Beam CT (CBCT) images served for 9 year follow-up of a patient with a non familial cherubism discovered at age 6, GCGG being disclosed 5 years later. Diagnoses were obtained based on clinical and radiological features and confirmed by genetic and histopathologic analyses.
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
MILICEVIC, Mladen ; Centre Hospitalier Universitaire de Liège - CHU > Département de Physique Médicale > Service médical de radiodiagnostic
Language :
English
Title :
Exceptional association of a non familial cherubism and giant cell central granuloma
Publication date :
April 2021
Event name :
ICDMFR 2021
Event organizer :
International Association of DentoMaxilloFacial Radiology