Article (Scientific journals)
Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors.
Anpilov, Sergey; Shemesh, Yair; Eren, Noa et al.
2020In Neuron, 107 (4), p. 644-655.e7
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Keywords :
Agonistic Behavior/physiology; Animals; Behavior, Animal/physiology; Mice; Neurons/metabolism/physiology; Optogenetics/methods; Oxytocin/metabolism; Social Behavior; Wireless Technology; aggression; optogenetics; oxytocin; social salience; wireless
Abstract :
[en] Complex behavioral phenotyping techniques are becoming more prevalent in the field of behavioral neuroscience, and thus methods for manipulating neuronal activity must be adapted to fit into such paradigms. Here, we present a head-mounted, magnetically activated device for wireless optogenetic manipulation that is compact, simple to construct, and suitable for use in group-living mice in an enriched semi-natural arena over several days. Using this device, we demonstrate that repeated activation of oxytocin neurons in male mice can have different effects on pro-social and agonistic behaviors, depending on the social context. Our findings support the social salience hypothesis of oxytocin and emphasize the importance of the environment in the study of social neuromodulators. Our wireless optogenetic device can be easily adapted for use in a variety of behavioral paradigms, which are normally hindered by tethered light delivery or a limited environment.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Anpilov, Sergey
Shemesh, Yair
Eren, Noa
Harony-Nicolas, Hala
Benjamin, Asaf
Dine, Julien
De Moura Oliveira, Vinicius Elias  ;  Université de Liège - ULiège > Neurosciences-Neuroendocrinology
Forkosh, Oren
Karamihalev, Stoyo
Hüttl, Rosa-Eva
Feldman, Noa
Berger, Ryan
Dagan, Avi
Chen, Gal
Neumann, Inga D.
Wagner, Shlomo
Yizhar, Ofer
Chen, Alon
More authors (8 more) Less
Language :
English
Title :
Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors.
Publication date :
2020
Journal title :
Neuron
ISSN :
0896-6273
eISSN :
1097-4199
Publisher :
Cell Press, Cambridge, United States - Massachusetts
Volume :
107
Issue :
4
Pages :
644-655.e7
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Available on ORBi :
since 31 May 2021

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