The role of 2-oxoglutarate dependent dioxygenases in gliomas and glioblastomas: hypoxic response and epigenetic reprogramming

Crake, Rebekah; Burgess, Eleanor; Royds, Janice; Phillips, Elisabeth; Vissers, Margreet; Dachs, Gabi

doi:10.3389/fonc.2021.619300

Article (Scientific journals)

The role of 2-oxoglutarate dependent dioxygenases in gliomas and glioblastomas: hypoxic response and epigenetic reprogramming

Crake, Rebekah; Burgess, Eleanor; Royds, Janice et al.

2021 • In Frontiers in Oncology, 11

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/260450

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10.3389/fonc.2021.619300

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Keywords :

Brain cancer; Ascorbate; demethylation

Abstract :

[en] Gliomas are a heterogeneous group of cancers that predominantly arise from glial cells in the brain, but may also arise from neural stem cells, encompassing low-grade glioma and high-grade glioblastoma. Whereas better diagnosis and new treatments have improved patient survival for many cancers, glioblastomas remain challenging with a highly unfavorable prognosis. This review discusses a super-family of enzymes, the 2-oxoglutarate dependent dioxygenase enzymes (2-OGDD) that control numerous processes including epigenetic modifications and oxygen sensing, and considers their many roles in the pathology of gliomas. We specifically describe in more detail the DNA and histone demethylases, and the hypoxia-inducible factor hydroxylases in the context of glioma, and discuss the substrate and cofactor requirements of the 2-OGDD enzymes. Better understanding of how these enzymes contribute to gliomas could lead to the development of new treatment strategies.

Disciplines :

Oncology

Author, co-author :

Crake, Rebekah ^✱; Université de Liège - ULiège > GIGA Cancer - Metastases Research Laboratory

Burgess, Eleanor ^✱

Royds, Janice

Phillips, Elisabeth

Vissers, Margreet

Dachs, Gabi

^✱ These authors have contributed equally to this work.

Language :

English

Title :

The role of 2-oxoglutarate dependent dioxygenases in gliomas and glioblastomas: hypoxic response and epigenetic reprogramming

Publication date :

25 March 2021

Journal title :

Frontiers in Oncology

eISSN :

2234-943X

Publisher :

Frontiers Media S.A., Switzerland

Volume :

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://www.frontiersin.org/articles/10.3389/fonc.2021.619300/full#h10

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since 29 May 2021

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