Analysis of gut microbiota in patients with parkinson’s disease

Gut microbiota; Parkinson’s disease; RNA 16S; Article; Bacteroides; Bacteroides coprocola; Bacteroides dorei; Bacteroides massiliensis; Bacteroides plebeus; Bifidobacterium; Blautia glucerasea; Catabacter; Catabacter hongkongensis; Christensenella; Christensenella minuta; Coprococcus eutactus; Dorea longicatena; Faecalibacterium; Lactobacillus; Lactobacillus mucosae; Lewy body; Methanobacteriaceae; Papillibacter cinnamivorans; Parkinson disease; Prevotella; Prevotella copri; Rumino coccuscallidus; Ruminococcus bromii; Ruminococcus callidus; Stoquefichus massiliensis; DNA barcoding; DNA sequence; Gram negative bacterium; Gram positive bacterium; Aged; Biodiversity; Case-Control Studies; DNA Barcoding, Taxonomic; DNA, Bacterial; Feces; Female; Gastrointestinal Microbiome; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Male; Middle Aged; Phylogeny; RNA, Ribosomal, 16S; Sequence Analysis, DNA

Abstract :

[en] Gut microbiota of patients with Parkinson’s disease and healthy volunteers was analyzed by the method of high throughput 16S rRNA sequencing of bacterial genomes. In patients with Parkinson’s diseases, changes in the content of 9 genera and 15 species of microorganisms were revealed: reduced content of Dorea, Bacteroides, Prevotella, Faecalibacterium, Bacteroides massiliensis, Stoquefichus massiliensis, Bacteroides coprocola, Blautia glucerasea, Dorea longicatena, Bacteroides dorei, Bacteroides plebeus, Prevotella copri, Coprococcus eutactus, and Ruminococcus callidus, and increased content of Christensenella, Catabacter, Lactobacillus, Oscillospira, Bifidobacterium, Christensenella minuta, Catabacter hongkongensis, Lactobacillus mucosae, Ruminococcus bromii, and Papillibacter cinnamivorans. This microbiological pattern of gut microflora can trigger local inflammation followed by aggregation of a-synuclein and generation of Lewy bodies. © 2017 Springer Science+Business Media New York.

Disciplines :

Life sciences: Multidisciplinary, general & others

Author, co-author :

Petrov, Viacheslav ; Siberian State Medical University (SSMU), 2, Moscow Trakt, Tomsk, 634050, Russian Federation

Saltykova, I. V.; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation

Zhukova, I. A.; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation

Alifirova, V. M.; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation

Zhukova, N. G.; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation

Dorofeeva, Y. B.; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russian Federation

Tyakht, A. V.; Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, Moscow, Russian Federation

Kovarsky, B. A.; Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, Moscow, Russian Federation

Alekseev, D. G.; Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, Moscow, Russian Federation

Kostryukova, E. S.; Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological Agency, Moscow, Russian Federation

More authors (9 more)

Language :

English

Title :

Analysis of gut microbiota in patients with parkinson’s disease

Publication date :

2017

Journal title :

Bulletin of Experimental Biology and Medicine

ISSN :

0007-4888

eISSN :

1573-8221

Publisher :

Springer New York LLC

Volume :

162

Issue :

Pages :

734-737

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 27 May 2021

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