Treatment of delayed puberty and hypogonadism in girls

[en] The therapeutic management of female delayed puberty depends more on the objectives than on the underlying cause. We will have to consider the development of sex characteristics, the occurrence of menarche and the promotion of growth. In this paper, we will review how girls with delayed puberty of different etiologies can benefit from the following therapeutic alternatives: follow-up without hormonal therapy; administration of growth hormone, anabolic steroids (e.g. oxandrolone) or estrogens and progestogens, and psychological support.

Disciplines :

Endocrinology, metabolism & nutrition

Author, co-author :

Heinrichs, Claudine

Bourguignon, Jean-Pierre ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie

Language :

English

Title :

Treatment of delayed puberty and hypogonadism in girls

Publication date :

1991

Journal title :

Hormone Research in Paediatrics

ISSN :

1663-2818

eISSN :

1663-2826

Publisher :

Karger, Basel, Switzerland

Volume :

Issue :

3-4

Pages :

147-152

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 May 2021

Statistics

Number of views

81 (1 by ULiège)

Number of downloads

127 (2 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

Bibliography

Bourguignon JP, Gaspard U: Delayed puberty in girls and primary amenorrhea; in Bardin CW (ed): Current Therapy in Endocrinology and Metabolism. New York, Dekker. 1991. pp 183-186.
Schaefer F, Seidel C, Blinding A, et al: Pubertal growth in chronic renal failure. Pediatr Res 1990;28:5-10.
Shalet SM: Treatment of constitutional delay in growth and puberty. Clin Endocrinol 1989:31:81-86.
Merimee TJ. Fineberg SE: Studies of the sex based variation of the growth hormone secretion. J Clin Endocrinol Metab 1971; 33:896.
Gourmelen P, Pham-Huu-Trung MT, Girard F: Transient partial hGH deficiency in prepubertal children with delay of growth. Pediatr Res 1979:13:221-224.
Ross JL, Pcscovitz OH, Barnes K. et al: Growth hormone secretory dynamics in children with precocious puberty. J Pediatr 1987:110:369-372.
Mauras N, Blizzard RM, Link K. et al: Augmentation of growth hormone secretion during puberty: Evidence of a pulse amplitude-modulated phenomenon. J Clin Endocrinol Metab 1987: 64:596-601.
Bourguignon JP. Vandeweghe M. Vanderschueren-Lodeweyckx M. et al: Hypopituitarism as a model of the relative effects of sex steroids and growth hormone on the pubertal growth spurt and final height; in Delemarre-van de Waal H, et al (eds): Control of the Onset of Puberty 111. Amsterdam. Elsevier. 1989, pp 329-342.
Darendeliler F, Hindmarsh PC, Preece MA, et al: Growth hormone increases rate of pubertal maturation. Acta Endocrinol (Copenh) 1990:122:414-416.
Job JC, Chaussain JL, Gamier P. et al: Dose-response relationship in the treatment of hypopituitary children with human growth hormone: A retrospective survey. Acta Paediatr Scand 1987(suppl 337):93-l05.
Price DA, Shalet SM, Clayton PE: Management of idiopathic growth hormone deficient patient during puberty. Acta Paediatr Scand 1988(suppl 347):44-5l.
Vanderschueren-Lodeweyck M, Van den Broek J, Wolter R, et al: Early initiation of growth hormone treatment: Influence on final height. Acta Paediatr Scand 1987(suppl 337):4-11.
Rosenfeld RG, Hintz RL, Johanson AJ, et al: Three-year results of a randomized prospective trial of mcthionyl human growth hormone and oxandrolone in Turner syndrome. J Pediatr 1988: 113:393-400.
Vanderschueren-Lodeweyckx M, Massa G, Maes M. et al: Growth-promoting effect of growth hormone and low dose ethinyl estradiol in girls with Turner's syndrome. J Clin Endocrinol Metab 1990;70:122-126.
Massa G, Vanderschueren-Lodeweyckx M, Craen M, et al: Growth hormone treatment of Turner syndrome patients with growth hormone deficiency. Eur J Pediatr. in press.
Joss EE, Schmidt HA, Zuppinger KA: Oxandrolone in constitutionally delayed growth: A longitudinal study up to final height. J Clin Endocrinol Metab 1989,69:1109-1115.
Link K, Blizzard RM, Evans WS, et al: The effect of androgens on the pulsatile release and the twenty-four-hour mean concentration of growth hormone in peripubertal males. J Clin Endocrinol Metab 1986;62:159-164.
Joss EE: Anabolic steroids in girls with Turner's syndrome. Acta Pediatr Scand I988(suppl 343):38-42.
Plotnick LP. Thompson RG. Beitins I. et al: Integrated concentrations of growth hormone correlated with stage of puberty and estrogen levels in girls. J Clin Endocrinol Metab 1974:38:436-439.
Rosenfield RL, Furlanetto R, Bock D: Relationship of somato-medin-C concentrations to pubertal changes. J Pediatr 1983; 103:723-728.
Corvol MT. Carroscosa A. Tsagris L, et al: Evidence for a direct in vitro action of sex steroids on rabbit cartilage cells during skeletal growth: Influence of age and sex. Endocrinology 1987: 120:1422-1429.
Rolland A. Mugnier E. Rappaport R, et al: Le traitcmeni du nanisme hypophysaire par I'hormone dc croissance humaine. Arch Fr Pediatr 1980:37:659-665.
Burns EC. Tanner JM. Preece MA. et al: Growth hormone treatment in children with craniopharyngioma: Final growth status. Clin Endocrinol 1981;14:587-595.
Ranke MB. Butenandt O: Idiopathic growth hormone deficiency: Final height to treatment with growth hormone and effects of puberty and sex steroids; in Frish H. Laron Z (eds): Induction of Puberty in Hypopituitarism. Ares. Serono Symposia, Rome 1988. Review 16. pp 85-97.
Bourguignon JP: Linear growth as a function of age at onset of puberty and sex steroid dosage. Endocr Rev 1988:9:467-488.
Lev-Ran A: Androgens, estrogens and the ultimate height in XO gonadal dysgenesis. Am J Dis Child 1977;131:648-649.
Ross JL, Cassorla FG, Skerda MC, et al: A preliminary study of the effect of estrogen dose on growth in Turner's syndrome. N Engl J Med 1983:309:1104-1106.
Ross JL, Long LM, Skerda MC, et al: Effect of low doses of estradiol on 6-month growth rates and predicted height in patients with Turner syndrome. J Pediatr 1986;109:950-953.
Martinez A. Heinrich JJ. Domene H. et al: Growth in Turner's syndrome: Long-term treatment with low dose ethinyl estradiol. J Clin Endocrinol Metab 1987;65:253-257.
Kastrup KW: Growth and development in girls with Turner's syndrome during early therapy with low doses of estradiol. Acta Endocrinol (Copenh) I986(suppl 279): 157-163.
Massa G, Vanderschueren-Lodeweyckx M, Malvaux P: Linear growth in patients with Turner syndrome: Influence of spontaneous puberty and parental height. Eur J Pediatr 1990:149:246-250.
Van Dop C. Burstein S. Conte FA. et al: Isolated gonadotropin deficiency in boys: Clinical characteristics and growth. J Pediatr 1987;11:684-690.
Sigurjonsdottir TJ. Hayles AB: Precocious puberty: A report of 96 cases. Am J Dis Child 1968:115:309-321.
Ranke MB. Hang F. Blum WF: Effect on growth of patients with Turner's syndrome treated with low estrogen doses. Acta Endocrinol (Copenh) 1986(suppl 279): 153-156.