Régulation de la sécrétion des gonadotrophines dans l'hypogonadisme hypogonadotrope

To day, from our experimental knowledges and our clinical experience in patients with hypogonadotrophic hypogonadism, different mechanisms may be considered. An impaired biosynthesis of the Pro-LHRH precursor resulting from the absence of appropriate hypothalamic mRNA may be considered. An altered (probably slowered) frequency of the hypothalamic generator of LHRH pulses may also account for some clinical situations. In contrast, we have so far no strong arguments for an excessive opiatergic inhibitory control of LHRH in patients with gonadotropin deficiency.