Article (Scientific journals)
Increase in transmitted resistance to non-nucleoside reverse transcriptase inhibitors among newly diagnosed HIV-1 infections in Europe
Frentz, Dineke; Van de Vijver, David AMC; Abecasis, Ana B et al.
2014In BMC Infectious Diseases, 14 (407), p. 1-12
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Keywords :
Europe; HIV-1; Resistance; Transmission
Abstract :
[en] Background : One out of ten newly diagnosed patients in Europe was infected with a virus carrying a drug resistant mutation. We analysed the patterns over time for transmitted drug resistance mutations (TDRM) using data from the European Spread program. Methods: Clinical, epidemiological and virological data from 4317 patients newly diagnosed with HIV-1 infection between 2002 and 2007 were analysed. Patients were enrolled using a pre-defined sampling strategy. Results: The overall prevalence of TDRM in this period was 8.9% (95% CI: 8.1-9.8). Interestingly, significant changes over time in TDRM caused by the different drug classes were found. Whereas nucleoside resistance mutations remained constant at 5%, a significant decline in protease inhibitors resistance mutations was observed, from 3.9% in 2002 to 1.6% in 2007 (p = 0.001). In contrast, resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) doubled from 2.0% in 2002 to 4.1% in 2007 (p = 0.004) with 58% of viral strains carrying a K103N mutation. Phylogenetic analysis showed that these temporal changes could not be explained by large clusters of TDRM. Conclusion: During the years 2002 to 2007 transmitted resistance to NNRTI has doubled to 4% in Europe. The frequent use of NNRTI in first-line regimens and the clinical impact of NNRTI mutations warrants continuedmonitoring.
Disciplines :
Immunology & infectious disease
Author, co-author :
Frentz, Dineke;  Erasmus Medical Center, Rotterdam, the Netherlands
Van de Vijver, David AMC;  Erasmus Medical Center, Rotterdam, the Netherlands
Abecasis, Ana B;  Centro de Malária e outras Doenças Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal
Albert, Jan;  Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden ; Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden
Hamouda, Osamah;  Robert Koch Institute, Berlin, Germany
Jorgensen, Louise B;  Statens Serum Institute, Copenhagen, Denmark
Kucherer, Claudia;  Robert Koch Institute, Berlin, Germany
Struck, Daniel;  Laboratory of Retrovirology, CRP-Santé, Luxembourg, Luxembourg
Schmit, Jean-Claude;  Laboratory of Retrovirology, CRP-Santé, Luxembourg, Luxembourg ; Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg
Vercauteren, Jurgen;  Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium
Balotta, Claudia;  University of Milan, Milan, Italy
Beshkov, Danail;  Department of Virology, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria
Camacho, Ricardo;  Centro de Malária e outras Doenças Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal ; Hospital Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portuga
Clotet, Bonaventura;  irsiCaixa AIDS Research Institute & Lluita contra la SIDA Foundation, Hospital Universitari “Germans Trias i Pujol”, Badalona, Spain
Coughlan, Suzie;  University College Dublin, Dublin, Ireland
Griskevicius, Algirdas;  National Public Health Surveillance Laboratory, Vilnius, Lithuania
Grossman, Zehava;  Sheba Medical Center, Tel Hashomer, Israel
Horban, Andrzej;  Warsaw Medical University and Hospital of Infectious Diseases, Warsaw, Poland
Kolupajeva, Tatjana;  Infectology Center of Latvia, Riga, Latvia
Korn, Klaus;  University of Erlangen-Nuremberg, Erlangen, Germany
Kostrikis, Leondios G;  University of Cyprus, Nicosia, Cyprus
Liitsola, Kirsi;  National Institute for Health and Welfare, Helsinki, Finland
Linka, Marek;  National Institute of Public Health, Prague, Czech Republic
Nielsen, Klaus;  Robert Koch Institute, Berlin, Germany
Otelea, Dan;  Molecular Diagnostics, “Prof. Dr. Matei Bals” Institute for Infectious Diseases, Bucharest, Romania
Paraskevis, Dimitrios;  Medical School, University of Athens, Athens, Greece
Paredes, Roger;  Hospital Egas Moniz, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal
Poljak, Mario;  University of Ljubljana, Ljubljana, Slovenia
Puchhammer-Stöckl, Elisabeth;  Medical University Vienna, Vienna, Austria
Sönnerborg, Anders;  Divisions of Infectious Diseases and Clinical Virology, Karolinska Institute, Stockholm, Sweden ; Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden
Stanekova, Danika;  Slovak Medical University, Bratislava, Slovakia
Stanojevic, Maja;  University of Belgrade School of Medicine, Belgrade, Serbia
Van Wijngaerden, Eric;  Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium
Wensing, Annemarie MJ;  Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands
Boucher, Charles AB;  Erasmus Medical Center, Rotterdam, the Netherlands
Asjo, Birgitta;  The Gade Institute, University of Bergen, Bergen, Norway > Section for Microbiology and Immunology
More authors (26 more) Less
Other collaborator :
VAIRA, Dolorès ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Unité de laboratoire - LRS Biomol
Language :
English
Title :
Increase in transmitted resistance to non-nucleoside reverse transcriptase inhibitors among newly diagnosed HIV-1 infections in Europe
Publication date :
21 July 2014
Journal title :
BMC Infectious Diseases
eISSN :
1471-2334
Publisher :
BioMed Central, United Kingdom
Volume :
14
Issue :
407
Pages :
1-12
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 14 May 2021

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