Article (Scientific journals)
Une physionomie comparée originale de l'activité clinique des antidépresseurs
ANSSEAU, Marc; Diricq, Stéphane; Bataille, Michel
1985In Acta Psychiatrica Belgica, 85 (5), p. 644-661
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Keywords :
Antidepressive Agents; Comparative Study; Depressive Disorder; English Abstract; Human
Abstract :
[en] In order to develop practical criteria to guide in the selection of antidepressant medication according to depressive symptomatology, we propose a graphical representation of the clinical activity of 24 antidepressants according to a 'star' model. Six parameters have been evaluated from 0 to 5 in comparison to reference drugs (rated 5) by 11 independent 'blind' psychiatrists expert in pharmacotherapy. Three parameters were used as measures of therapeutic activity: antidepressant, psychostimulant, and anxiolytic, with iproniazide 75 mg/d, metamphetamine 15 mg/d, and diazepam 20 mg/d as reference drugs respectively. Three additional parameters assessed the level of side-effects: anticholinergic, sedative, and hypotensive, with atropine 0.75 mg/d, phenobarbital 200 mg/d, and iproniazide 75 mg/d as reference drugs respectively. The defined dose represented the standard maintenance daily dose for depressive outpatients. Mean values for each parameter, rounded off to the closest number, were used for the graphical representation. Results showed an excellent agreement among evaluators for the clinical profile of classical tricyclic and MAOI antidepressants, but serious divergences for the more recent drugs (e.g., viloxazine and mianserine), possibly reflecting more atypical or more variable clinical profile of these compounds.
Disciplines :
Treatment & clinical psychology
Author, co-author :
ANSSEAU, Marc ;  Université de Liège - ULg
Diricq, Stéphane ;  Centre Hospitalier Universitaire de Liège - CHU
Bataille, Michel;  Unite de Psychiatrie Biologique et de Psychopharmacologie, Centre Hospitalier Universitaire, B-4000 Sart Tilman, Belgium
Language :
French
Title :
Une physionomie comparée originale de l'activité clinique des antidépresseurs
Alternative titles :
[en] A new approach to the comparative physiognomy of the clinical activity of antidepressants
Publication date :
1985
Journal title :
Acta Psychiatrica Belgica
ISSN :
0300-8967
Publisher :
Acta Medica Belgica, Belgium
Volume :
85
Issue :
5
Pages :
644-661
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
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