Radioimmunoassay of serum luteinizing hormone releasing hormone (LH-RH) after intra-nasal administration and evaluation of the pituitary gonadotrophic response

Serum levels of LH‐RH, LH and FSH were measured by radioimmunoassay at frequent intervals in four young men following the intranasal administration of 2 mg synthetic LH‐RH. The initial rise in serum LH‐RH was seen at 2.5 min and the peak was reached at 15 min. There was a rapid response in serum LH, the peak occurring between 30 and 45 min, while FSH levels did not change significantly. It was calculated that 1.25% of the dose was absorbed. The intranasal administration of LH‐RH appears to have considerable therapeutic potential. Copyright © 1974, Wiley Blackwell. All rights reserved