Article (Scientific journals)
EANM position paper on the role of radiobiology in nuclear medicine.
Aerts, An; Eberlein, Uta; Holm, Sören et al.
2021In European Journal of Nuclear Medicine and Molecular Imaging
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Keywords :
Biodosimetry; Biomarkers; Dosimetry; Radiobiology; Radionuclide therapy
Abstract :
[en] With an increasing variety of radiopharmaceuticals for diagnostic or therapeutic nuclear medicine as valuable diagnostic or treatment option, radiobiology plays an important role in supporting optimizations. This comprises particularly safety and efficacy of radionuclide therapies, specifically tailored to each patient. As absorbed dose rates and absorbed dose distributions in space and time are very different between external irradiation and systemic radionuclide exposure, distinct radiation-induced biological responses are expected in nuclear medicine, which need to be explored. This calls for a dedicated nuclear medicine radiobiology. Radiobiology findings and absorbed dose measurements will enable an improved estimation and prediction of efficacy and adverse effects. Moreover, a better understanding on the fundamental biological mechanisms underlying tumor and normal tissue responses will help to identify predictive and prognostic biomarkers as well as biomarkers for treatment follow-up. In addition, radiobiology can form the basis for the development of radiosensitizing strategies and radioprotectant agents. Thus, EANM believes that, beyond in vitro and preclinical evaluations, radiobiology will bring important added value to clinical studies and to clinical teams. Therefore, EANM strongly supports active collaboration between radiochemists, radiopharmacists, radiobiologists, medical physicists, and physicians to foster research toward precision nuclear medicine.
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Aerts, An
Eberlein, Uta
Holm, Sören
Hustinx, Roland  ;  Université de Liège - ULiège > Département des sciences cliniques > Médecine nucléaire
Konijnenberg, Mark
Strigari, Lidia
van Leeuwen, Fijs W. B.
Glatting, Gerhard
Lassmann, Michael
Language :
English
Title :
EANM position paper on the role of radiobiology in nuclear medicine.
Publication date :
2021
Journal title :
European Journal of Nuclear Medicine and Molecular Imaging
ISSN :
1619-7070
eISSN :
1619-7089
Publisher :
Springer, Germany
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 03 May 2021

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