Poster (Scientific congresses and symposiums)
Continuous Flow Upgrading of Glycerol toward Oxiranes and Active Pharmaceutical Ingredients thereof
Morodo Martinez, Romain; Gerardy, Romaric; Petit, Guillaume et al.
2020Journée-Rencontre des Jeunes Chimistes
 

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Keywords :
Continous-flow; Biomass; Active pharmaceutical ingredient
Abstract :
[en] The progressive depletion of fossil resources and a global environmental awareness stimulates research toward a transition for more sustainable supplies Glycerol, which is nowadays obtained as a by product of the biodiesel production, presents a significant industrial potential and can be upgraded in a large variety of value added building blocks We present herein a robust multi module continuous flow procedure for the valorization of glycerol towards active pharmaceutical ingredients ( through the intermediate formation of epichlorohydrin The first module is dedicated to the valorization of glycerol into oxiranes by a hydrochlorination dechlorination concatenated sequence involving economically and environmentally favorable conditions, an organocatalyst and an in line separation of the two products. Finally, biobased epichlorohydrin is further utilized for the preparation of β-amino alcohol APIs including propranolol ( WHO essential), naftopidil (prostatic hyperplasia) and alprenolol (angina pectoris) within a concatenable Williamson/ aminolysis sequence using a FDA class 3 solvent (DMSO).
Research center :
CENTER FOR INTEGRATED TECHNOLOGY AND ORGANIC SYNTHESIS
Disciplines :
Chemistry
Author, co-author :
Morodo Martinez, Romain  ;  Université de Liège - ULiège > Département de chimie (sciences) > Synthèse organique appliquée
Gerardy, Romaric ;  Université de Liège - ULiège > Département de chimie (sciences) > CITOS
Petit, Guillaume ;  Université de Liège - ULiège > Département de chimie (sciences) > Synthèse organique appliquée
Monbaliu, Jean-Christophe  ;  Université de Liège - ULiège > Département de chimie (sciences) > Synthèse organique appliquée
Language :
English
Title :
Continuous Flow Upgrading of Glycerol toward Oxiranes and Active Pharmaceutical Ingredients thereof
Publication date :
06 March 2020
Number of pages :
A0
Event name :
Journée-Rencontre des Jeunes Chimistes
Event organizer :
Jeunes Chimistes de la SRC
Event place :
Namur, Belgium
Event date :
6 mars 2020
Available on ORBi :
since 03 May 2021

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