Article (Scientific journals)
Duration of benzodiazepine clinical activity: Lack of direct relationship with plasma half-life - A comparison of single vs divided dosage schedules of prazepam
ANSSEAU, Marc; Doumont, Adrienne; von Frenckell, Rémy et al.
1984In Psychopharmacology, 84 (3), p. 293-298
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Keywords :
Anxiety disorders; Benzodiazepines; Plasma pharmacokinetics; Prazepam; Adult; Anti-Anxiety Agents, Benzodiazepine; Anxiety; Comparative Study; Female; Half-Life; Human; Male; Middle Age; Psychiatric Status Rating Scales; Time Factors
Abstract :
[en] The anxiolytic activity and tolerance of two dosage schedules of prazepam, a long plasma half-life benzodiazepine, were compared under double-blind conditions in two groups of 10 inpatients each who met Research Diagnostic Criteria for Generalized Anxiety Disorder and presented chronic and severe symptomatology. Patients received prazepam 40 mg per day on one of two dosage schedules: 1) divided dosage (DD) - 10 mg in the morning and at noon and 20 mg in the evening; or 2) single dosage (SD) - 40 mg in the evening. The 3 weeks of therapy were preceded and followed by 1 week of wash-out for baseline and follow-up assessments, which were performed weekly with the Hamilton Anxiety Scale, Clinical Global Impression, rating of morning drowsiness and evening worsening of symptoms, and patient self-rating of anxiety by means of a visual analogue scale performed both in the morning and in the afternoon. The results showed a clear superiority of the DD over the SD schedule: better anxiolytic efficacy on the Hamilton Anxiety Scale (P<0.0005) and on both morning and afternoon visual analogue scales (P<0.01 and P<0.0002); less morning drowsiness (P<0.0001); and steadier anxiolytic effect during the daytime, as globally rated by the investigator (P<0.0001) or measured by morning-afternoon differences on the visual analogue scale (P<0.005). These results suggest that plasma pharmacokinetics alone may not be sufficient to predict the duration of benzodiazepine anxiolytic activity. © 1984 Springer-Verlag.
Disciplines :
Psychiatry
Author, co-author :
ANSSEAU, Marc ;  Université de Liège - ULg
Doumont, Adrienne ;  Psychopharmacology Unit, University Hospital 'de Bavière', University of Liège Medical School, Liège, B-4020, Belgium
von Frenckell, Rémy ;  Psychopharmacology Unit, University Hospital 'de Bavière', University of Liège Medical School, Liège, B-4020, Belgium
Collard, Jackie 
Language :
English
Title :
Duration of benzodiazepine clinical activity: Lack of direct relationship with plasma half-life - A comparison of single vs divided dosage schedules of prazepam
Publication date :
1984
Journal title :
Psychopharmacology
ISSN :
0033-3158
eISSN :
1432-2072
Publisher :
Springer, Germany
Volume :
84
Issue :
3
Pages :
293-298
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 01 May 2021

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