Bok J, Chang W, Wu DK, (2007) Patterning and morphogenesis of the vertebrate inner ear. Int J Dev Biol 51: 521-533.
Fekete DM, Wu DK, (2002) Revisiting cell fate specification in the inner ear. Curr Opin Neurobiol 12: 35-42.
Alsina B, Giraldez F, Pujades C, (2009) Patterning and cell fate in ear development. Int J Dev Biol 53: 1503-1513.
Fritzsch B, Beisel KW, Hansen LA, (2006) The molecular basis of neurosensory cell formation in ear development: a blueprint for hair cell and sensory neuron regeneration? Bioessays 28: 1181-1193.
Cotanche DA, Kaiser CL, (2010) Hair cell fate decisions in cochlear development and regeneration. Hear Res 266: 18-25.
Kelley MW, Driver EC, Puligilla C, (2009) Regulation of cell fate and patterning in the developing mammalian cochlea. Curr Opin Otolaryngol Head Neck Surg 17: 381-387.
Oesterle EC, Campbell S, Taylor RR, Forge A, Hume CR, (2008) Sox2 and JAGGED1 expression in normal and drug-damaged adult mouse inner ear. J Assoc Res Otolaryngol 9: 65-89.
Hume CR, Bratt DL, Oesterle EC, (2007) Expression of LHX3 and SOX2 during mouse inner ear development. Gene Expr Patterns 7: 798-807.
Neves J, Kamaid A, Alsina B, Giraldez F, (2007) Differential expression of Sox2 and Sox3 in neuronal and sensory progenitors of the developing inner ear of the chick. J Comp Neurol 503: 487-500.
Kiernan AE, Pelling AL, Leung KK, Tang AS, Bell DM, et al. (2005) Sox2 is required for sensory organ development in the mammalian inner ear. Nature 434: 1031-1035.
Neves J, Parada C, Chamizo M, Giraldez F, (2011) Jagged 1 regulates the restriction of Sox2 expression in the developing chicken inner ear: a mechanism for sensory organ specification. Development 138: 735-744.
Dabdoub A, Puligilla C, Jones JM, Fritzsch B, Cheah KS, et al. (2008) Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea. Proc Natl Acad Sci U S A 105: 18396-18401.
Daudet N, Ariza-McNaughton L, Lewis J, (2007) Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear. Development 134: 2369-2378.
Kiernan AE, Xu J, Gridley T, (2006) The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear. PLoS Genet 2: e4.
Daudet N, Lewis J, (2005) Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair-cell differentiation. Development 132: 541-551.
Hartman BH, Reh TA, Bermingham-McDonogh O, (2010) Notch signaling specifies prosensory domains via lateral induction in the developing mammalian inner ear. Proc Natl Acad Sci U S A 107: 15792-15797.
Pan W, Jin Y, Stanger B, Kiernan AE, (2010) Notch signaling is required for the generation of hair cells and supporting cells in the mammalian inner ear. Proc Natl Acad Sci U S A 107: 15798-15803.
Guillemot F, (2007) Spatial and temporal specification of neural fates by transcription factor codes. Development 134: 3771-3780.
Bylund M, Andersson E, Novitch BG, Muhr J, (2003) Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nat Neurosci 6: 1162-1168.
Holmberg J, Hansson E, Malewicz M, Sandberg M, Perlmann T, et al. (2008) SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation. Development 135: 1843-1851.
Graham V, Khudyakov J, Ellis P, Pevny L, (2003) SOX2 functions to maintain neural progenitor identity. Neuron 39: 749-765.
Sandberg M, Kallstrom M, Muhr J, (2005) Sox21 promotes the progression of vertebrate neurogenesis. Nat Neurosci 8: 995-1001.
Uchikawa M, Kamachi Y, Kondoh H, (1999) Two distinct subgroups of Group B Sox genes for transcriptional activators and repressors: their expression during embryonic organogenesis of the chicken. Mech Dev 84: 103-120.
Hosoya M, Fujioka M, Matsuda S, Ohba H, Shibata S, et al. (2011) Expression and Function of Sox21 During Mouse Cochlea Development. Neurochem Res.
Hamburger V, Hamilton HL, (1992) A series of normal stages in the development of the chick embryo. 1951. Dev Dyn 195: 231-272.
Sato Y, Kasai T, Nakagawa S, Tanabe K, Watanabe T, et al. (2007) Stable integration and conditional expression of electroporated transgenes in chicken embryos. Dev Biol 305: 616-624.
Takebayashi K, Akazawa C, Nakanishi S, Kageyama R, (1995) Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element. J Biol Chem 270: 1342-1349.
Freeman S, Chrysostomou E, Kawakami K, Takahashi Y, Daudet N, (2012) Tol2-mediated gene transfer and in ovo electroporation of the otic placode: a powerful and versatile approach for investigating embryonic development and regeneration of the chicken inner ear. Methods Mol Biol 916: 127-139.
Bartolami S, Goodyear R, Richardson G, (1991) Appearance and distribution of the 275 kD hair-cell antigen during development of the avian inner ear. J Comp Neurol 314: 777-788.
Goodyear RJ, Legan PK, Christiansen JR, Xia B, Korchagina J, et al. (2010) Identification of the hair cell soma-1 antigen, HCS-1, as otoferlin. J Assoc Res Otolaryngol 11: 573-586.
Adam J, Myat A, Le Roux I, Eddison M, Henrique D, et al. (1998) Cell fate choices and the expression of Notch, Delta and Serrate homologues in the chick inner ear: parallels with Drosophila sense-organ development. Development 125: 4645-4654.
Henrique D, Adam J, Myat A, Chitnis A, Lewis J, et al. (1995) Expression of a Delta homologue in prospective neurons in the chick. Nature 375: 787-790.
Bermingham-McDonogh O, Oesterle EC, Stone JS, Hume CR, Huynh HM, et al. (2006) Expression of Prox1 during mouse cochlear development. J Comp Neurol 496: 172-186.
Stone JS, Shang JL, Tomarev S, (2003) Expression of Prox1 defines regions of the avian otocyst that give rise to sensory or neural cells. J Comp Neurol 460: 487-502.
Molea D, Stone JS, Rubel EW, (1999) Class III beta-tubulin expression in sensory and nonsensory regions of the developing avian inner ear. J Comp Neurol 406: 183-198.
Goodyear R, Holley M, Richardson G, (1995) Hair and supporting-cell differentiation during the development of the avian inner ear. J Comp Neurol 351: 81-93.
Takahashi Y, Watanabe T, Nakagawa S, Kawakami K, Sato Y, (2008) Transposon-mediated stable integration and tetracycline-inducible expression of electroporated transgenes in chicken embryos. Methods Cell Biol 87: 271-280.
Bermingham NA, Hassan BA, Price SD, Vollrath MA, Ben-Arie N, et al. (1999) Math1: an essential gene for the generation of inner ear hair cells. Science 284: 1837-1841.
Zheng J, Gao W, (2000) Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears. Nat Neurosci 3: 580-586.
Helms AW, Abney AL, Ben-Arie N, Zoghbi HY, Johnson JE, (2000) Autoregulation and multiple enhancers control Math1 expression in the developing nervous system. Development 127: 1185-1196.
Avilion AA, Nicolis SK, Pevny LH, Perez L, Vivian N, et al. (2003) Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev 17: 126-140.
Taranova OV, Magness ST, Fagan BM, Wu Y, Surzenko N, et al. (2006) SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Genes Dev 20: 1187-1202.
Mak AC, Szeto IY, Fritzsch B, Cheah KS, (2009) Differential and overlapping expression pattern of SOX2 and SOX9 in inner ear development. Gene Expr Patterns 9: 444-453.
Sweet EM, Vemaraju S, Riley BB, (2011) Sox2 and Fgf interact with Atoh1 to promote sensory competence throughout the zebrafish inner ear. Dev Biol 358: 113-121.
Millimaki BB, Sweet EM, Riley BB, (2010) Sox2 is required for maintenance and regeneration, but not initial development, of hair cells in the zebrafish inner ear. Developmental Biology 338: 262-269.
Neves J, Uchikawa M, Bigas A, Giraldez F, (2012) The prosensory function of sox2 in the chicken inner ear relies on the direct regulation of atoh1. PLoS One 7: e30871.
Ahmed M, Wong EY, Sun J, Xu J, Wang F, et al. (2012) Eya1-six1 interaction is sufficient to induce hair cell fate in the cochlea by activating atoh1 expression in cooperation with sox2. Dev Cell 22: 377-390.
Ferletta M, Caglayan D, Mokvist L, Jiang Y, Kastemar M, et al. (2011) Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells. Int J Cancer 129: 45-60.
Woolfe A, Goodson M, Goode DK, Snell P, McEwen GK, et al. (2005) Highly conserved non-coding sequences are associated with vertebrate development. PLoS Biol 3: e7.
Brignull HR, Raible DW, Stone JS, (2009) Feathers and fins: non-mammalian models for hair cell regeneration. Brain Res 1277: 12-23.
Collado MS, Burns JC, Hu Z, Corwin JT, (2008) Recent advances in hair cell regeneration research. Curr Opin Otolaryngol Head Neck Surg 16: 465-471.
Woods C, Montcouquiol M, Kelley MW, (2004) Math1 regulates development of the sensory epithelium in the mammalian cochlea. Nat Neurosci 7: 1310-1318.
Gubbels SP, Woessner DW, Mitchell JC, Ricci AJ, Brigande JV, (2008) Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer. Nature 455: 537-541.
Millimaki BB, Sweet EM, Dhason MS, Riley BB, (2007) Zebrafish atoh1 genes: classic proneural activity in the inner ear and regulation by Fgf and Notch. Development 134: 295-305.
Shou J, Zheng J, Gao W, (2003) Robust generation of new hair cells in the mature mammalian inner ear by adenoviral expression of Hath1. Mol Cell Neurosci 23: 169-179.
Liu Z, Dearman JA, Cox BC, Walters BJ, Zhang L, et al. (2012) Age-dependent in vivo conversion of mouse cochlear pillar and deiters' cells to immature hair cells by Atoh1 ectopic expression. J Neurosci 32: 6600-6610.
Kelly MC, Chang Q, Pan A, Lin X, Chen P, (2012) Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal Mammalian cochlea in vivo. J Neurosci 32: 6699-6710.
White P, Doetzlhofer A, Lee Y, Groves A, Segil N, (2006) Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells. Nature 441: 984-987.
Lin V, Golub JS, Nguyen TB, Hume CR, Oesterle EC, et al. (2011) Inhibition of Notch activity promotes nonmitotic regeneration of hair cells in the adult mouse utricles. J Neurosci 31: 15329-15339.
Collado MS, Thiede BR, Baker W, Askew C, Igbani LM, et al. (2011) The postnatal accumulation of junctional E-cadherin is inversely correlated with the capacity for supporting cells to convert directly into sensory hair cells in mammalian balance organs. J Neurosci 31: 11855-11866.
