Article (Scientific journals)
The Surfactin-Like Lipopeptides From Bacillus spp.: Natural Biodiversity and Synthetic Biology for a Broader Application Range
Théatre, Ariane; Cano-Prieto, Carolina; Bartolini, Marco et al.
2021In Frontiers in Bioengineering and Biotechnology, 9, p. 118
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Abstract :
[en] Surfactin is a lipoheptapeptide produced by several Bacillus species and identified for the first time in 1969. At first, the biosynthesis of this remarkable biosurfactant was described in this review. The peptide moiety of the surfactin is synthesized using huge multienzymatic proteins called NonRibosomal Peptide Synthetases. This mechanism is responsible for the peptide biodiversity of the members of the surfactin family. In addition, on the fatty acid side, fifteen different isoforms (from C12 to C17) can be incorporated so increasing the number of the surfactin-like biomolecules. The review also highlights the last development in metabolic modeling and engineering and in synthetic biology to direct surfactin biosynthesis but also to generate novel derivatives. This large set of different biomolecules leads to a broad spectrum of physico-chemical properties and biological activities. The last parts of the review summarized the numerous studies related to the production processes optimization as well as the approaches developed to increase the surfactin productivity of Bacillus cells taking into account the different steps of its biosynthesis from gene transcription to surfactin degradation in the culture medium.
Disciplines :
Biochemistry, biophysics & molecular biology
Microbiology
Biotechnology
Author, co-author :
Théatre, Ariane ;  Université de Liège - ULiège > Département GxABT > Microbial, food and biobased technologies
Cano-Prieto, Carolina
Bartolini, Marco
Laurin, Yoann ;  Université de Liège - ULiège > Département GxABT > Chimie des agro-biosystèmes
Deleu, Magali  ;  Université de Liège - ULiège > Département GxABT > Chimie des agro-biosystèmes
Niehren, Joachim
Fida, Tarik
Gerbinet, Saïcha ;  Université de Liège - ULiège > Department of Chemical Engineering > PEPs (Product, Environment, Processes)
Alanjary, Mohammad
Medema, Marnix H.
Léonard, Angélique  ;  Université de Liège - ULiège > Department of Chemical Engineering > PEPs (Product, Environment, Processes)
Lins, Laurence  ;  Université de Liège - ULiège > Département GxABT > Chimie des agro-biosystèmes
Arabolaza, Ana
Gramajo, Hugo
Gross, Harald
Jacques, Philippe ;  Université de Liège - ULiège > Département GxABT > Microbial, food and biobased technologies
More authors (6 more) Less
Language :
English
Title :
The Surfactin-Like Lipopeptides From Bacillus spp.: Natural Biodiversity and Synthetic Biology for a Broader Application Range
Publication date :
2021
Journal title :
Frontiers in Bioengineering and Biotechnology
eISSN :
2296-4185
Publisher :
Frontiers Research Foundation, Switzerland
Volume :
9
Pages :
118
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
ERACoBioTech program (BestBioSurf project)
Commentary :
This work was founded by the ERACoBioTech program (BestBioSurf project), the European INTERREG Va SmartBioControl/Bioscreen project and the national funding agencies, the Walloon Region (Belgium), the Dutch Research Council (NWO) (the Netherlands), the Agency for Renewable Resources (FNR) (Germany), the Federal Ministry of Food and Agriculture (Germany), and the Ministry of Science, Technology and Innovation (Argentina) and Innovate UK (the United Kingdom)
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