Microchip electrophoresis: A suitable analytical technique for pharmaceuticals quality control ? A critical review

Dispas, Amandine; Emonts, Paul; Fillet, Marianne

doi:10.1016/j.trac.2021.116266

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Article (Scientific journals)

Microchip electrophoresis: A suitable analytical technique for pharmaceuticals quality control ? A critical review

Dispas, Amandine; Emonts, Paul; Fillet, Marianne

2021 • In TrAC: Trends in Analytical Chemistry, 139, p. 116226

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/258620

DOI
10.1016/j.trac.2021.116266

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Keywords :

Microchip electrophoresis; Lab-on-a-chip; Pharmaceutical quality control; Miniaturization; Good manufacturing practices

Abstract :

[en] Quality control (QC) is a major concern in the pharmaceutical industry to ensure medicines quality and patient's safety. QC analysis are currently performed using several well-known separative and spectroscopic techniques. However, current trends are focused on the development of high performance techniques for reducing analysis time and cost and decreasing ecological footprint. In this context, analytical scientists developed microfluidic techniques such as microchip electrophoresis (MCE). This paper provides an overview of MCE system development and applications in perspectives with the requirements of QC analysis. The objective of the present review is to evaluate if MCE could be, now or in the future, a suitable alternative for pharmaceutical quality control. The quantitative performances of published MCE methods are deeply discussed using precision criterion (RSD) as a common thread.

Research Center/Unit :

CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège

Disciplines :

Chemistry
Pharmacy, pharmacology & toxicology

Author, co-author :

Dispas, Amandine ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Emonts, Paul ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Fillet, Marianne ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Language :

English

Title :

Microchip electrophoresis: A suitable analytical technique for pharmaceuticals quality control ? A critical review

Publication date :

June 2021

Journal title :

TrAC: Trends in Analytical Chemistry

ISSN :

0165-9936

eISSN :

1879-3142

Publisher :

Elsevier, Amsterdam, Netherlands

Volume :

139

Pages :

116226

Peer reviewed :

Peer Reviewed verified by ORBi

Name of the research project :

SMALLPHARE

Funders :

FEDER - Fonds Européen de Développement Régional

Available on ORBi :

since 05 April 2021

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