Article (Scientific journals)
Controlled Comparison of Two Anxiolytic Benzodiazepines, Cloxazolam and Bromazepam
Ansseau, Marc; von Frenckell, Rémy
1990In Neuropsychobiology, 24 (1), p. 25-29
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Keywords :
Cloxozolam; Bromazepam; Benzodiazepines; Anxiolytic; Anxiety
Abstract :
[en] The clinical activity and the tolerance of cloxazolam (4 mg/day), a new anxiolytic benzodiazepine, was compared to bromazepam (12 mg/day) in two parallel groups of 427 and 410 psychiatric outpatients, respectively. The duration of the study was 4 weeks with clinical assessments at inclusion and after 2 and 4 weeks of therapy by the Hamilton anxiety scale and visual analogue scales. While the Hamilton anxiety scale did not exhibit significant differences between the two benzodiazepines, visual analogue scales showed significant superiority of cloxazolam over bromazepam on psychological anxiety, somatic anxiety, depressed mood, and sleep, with a lack of significant difference related to the sedative effect, but less muscle-relaxant effect with cloxazolam than with bromazepam. The better efficacy and tolerance of cloxazolam compared to bromazepam was confirmed by the global assessments using visual analogue scales; moreover, a significantly larger proportion of patients in the cloxazolam group wanted to continue the same treatment.
Disciplines :
Treatment & clinical psychology
Author, co-author :
Ansseau, Marc ;  Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
von Frenckell, Rémy 
Language :
English
Title :
Controlled Comparison of Two Anxiolytic Benzodiazepines, Cloxazolam and Bromazepam
Publication date :
1990
Journal title :
Neuropsychobiology
ISSN :
0302-282X
eISSN :
1423-0224
Publisher :
Karger, Basel, Switzerland
Volume :
24
Issue :
1
Pages :
25-29
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 March 2021

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