GC×GC; Comprehensive gas chromatography; Untargeted metabolomics; QC system; Bias control; Effect size; Correlations; Crohn's disease; Colorectal cancer
Abstract :
[en] Metabolomics in a clinical context faces many analytical challenges. GC×GC-TOFMS has much higher sensitivity and resolution, therefore much higher untargeted capabilities than GC-MS but is still largely neglected in comparison. In front of that situation, the aim of the thesis was to develop methods to exploit the performances of GC×GC-(HR)TOF-MS in untargeted metabolomics in a clinical context, with the underlying goal of extending its use relatively to 1D GC-MS.
Research Center/Unit :
MolSys - Molecular Systems - ULiège
Disciplines :
Chemistry
Author, co-author :
Di Giovanni, Nicolas ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique, organique et biologique
Language :
English
Title :
Development of multidimensional approaches for metabolomics
