Article (Scientific journals)
Controlled Comparison of Buspirone and Oxazepam in Generalized Anxiety
Ansseau, Marc; Papart, Patrick; Gérard, Marie-Anne et al.
1990In Neuropsychobiology, 24 (2), p. 74-78
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Keywords :
Buspirone; Oxazepam; Genralized anxiety disorder; Benzodiazepine; Anxiolytic
Abstract :
[en] The anxiolytic activity, the tolerance, and the withdrawal symptoms of buspirone and oxazepam were compared in two groups of 14 and 12 outpatients, respectively, suffering from generalized anxiety in a double-blind study with random allocation of patients. The 6-week active period was preceded and followed by 1 and 2 weeks on placebo, respectively. Clinical assessments were performed before and after the predrug placebo period and every 2 weeks thereafter and included Hamilton anxiety and depression scales and AMDP anxiety subscale. The initial daily dose was 15 mg buspirone or 45 mg oxazepam in 3 intakes and the mean final daily doses were 22.2 and 55.8 mg, respectively. Results showed a slower anxiolytic activity of buspirone compared to oxazepam with less improvement after 2 weeks of treatment. The rebound anxiety following abrupt discontinuation of the drug and the level of side effects did not significantly differ between the two compounds.
Disciplines :
Treatment & clinical psychology
Author, co-author :
Ansseau, Marc ;  Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
Papart, Patrick ;  Université de Liège - ULiège > Département des sciences cliniques > Psycho. quantitative - Psychiatrie légale et sociale
Gérard, Marie-Anne;  Centre Hospitalier Universitaire de Liège - CHU
von Frenckell, Rémy ;  Université de Liège - ULiège > Psychiatrie et psychologie médicale
Franck, Georges ;  Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Controlled Comparison of Buspirone and Oxazepam in Generalized Anxiety
Publication date :
1990
Journal title :
Neuropsychobiology
ISSN :
0302-282X
eISSN :
1423-0224
Publisher :
Karger, Basel, Switzerland
Volume :
24
Issue :
2
Pages :
74-78
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 March 2021

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